Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Gautier Mark Arthur Ndong Ntoutoume (1) , Robert Granet (1) , Jean-Pierre Mbakidi (1) , Frédérique Brégier (1) , David Yannick Leger (1) , Chloé Fidanzi-Dugas (1) , Vincent Lequart (2) , Nicolas Y. Joly (2) , Bertrand Liagre (1) , Vincent Chaleix (1) , Vincent Sol (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 UA - Université d'Artois

The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.

Mots clés: Cancer cells; Cellulose nanocrystals; Curcumin; Drug delivery; Nanoparticles

Domaines: Chimie organique; Biochimie, Biologie Moléculaire

Gautier Mark Arthur Ndong Ntoutoume, Robert Granet, Jean-Pierre Mbakidi, Frédérique Brégier, David Yannick Leger, et al.. Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems. Bioorganic and Medicinal Chemistry Letters, 2016, 26, pp.941-945. ⟨10.1016/j.bmcl.2015.12.060⟩. ⟨hal-01257118⟩