The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Developmental Cell Année : 2015

The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila.

Résumé

Left-right (LR) asymmetry is essential for organ development and function in metazoans, but how initial LR cue is relayed to tissues still remains unclear. Here, we propose a mechanism by which the Drosophila LR determinant Myosin ID (MyoID) transfers LR information to neighboring cells through the planar cell polarity (PCP) atypical cadherin Dachsous (Ds). Molecular interaction between MyoID and Ds in a specific LR organizer controls dextral cell polarity of adjoining hindgut progenitors and is required for organ looping in adults. Loss of Ds blocks hindgut tissue polarization and looping, indicating that Ds is a crucial factor for both LR cue transmission and asymmetric morphogenesis. We further show that the Ds/Fat and Frizzled PCP pathways are required for the spreading of LR asymmetry throughout the hindgut progenitor tissue. These results identify a direct functional coupling between the LR determinant MyoID and PCP, essential for non-autonomous propagation of early LR asymmetry.
Fichier principal
Vignette du fichier
PIIS1534580715003147.pdf (5.98 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01254733 , version 1 (10-02-2021)

Identifiants

Citer

Nicanor González-Morales, Charles Géminard, Gaëlle Lebreton, Delphine Cerezo, Jean-Baptiste Coutelis, et al.. The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila.. Developmental Cell, 2015, 33 (6), pp.675-89. ⟨10.1016/j.devcel.2015.04.026⟩. ⟨hal-01254733⟩
53 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More