K. Park, L. Martelotto, and M. Peifer, A crucial requirement for Hedgehog signaling in small cell lung cancer, Nature Medicine, vol.128, issue.11, pp.1504-1512, 2011.
DOI : 10.1101/gad.1902910

Z. Yuan, J. Goetz, and S. Singh, Frequent requirement of hedgehog signaling in non-small cell lung carcinoma, Oncogene, vol.207, issue.7, pp.1046-55, 2007.
DOI : 10.1038/sj.onc.1209860

I. Gialmanidis, V. Bravou, S. Amanetopoulou, J. Varakis, H. Kourea et al., Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas, Lung Cancer, vol.66, issue.1, pp.64-74, 2009.
DOI : 10.1016/j.lungcan.2009.01.007

G. Raz, K. Allen, and C. Kingsley, Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer, Lung Cancer, vol.76, issue.2, pp.191-197, 2012.
DOI : 10.1016/j.lungcan.2011.10.015

W. Travis, E. Brambilla, and M. Noguchi, International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma, Journal of Thoracic Oncology, vol.6, issue.2, pp.244-85, 2011.
DOI : 10.1097/JTO.0b013e318206a221

URL : https://hal.archives-ouvertes.fr/inserm-00561753

Y. Wang, C. Chang, and C. Lin, Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma, Head & Neck, vol.8, issue.11, pp.1556-61, 2012.
DOI : 10.1002/hed.21958

R. Jokoji, T. Yamasaki, and S. Minami, Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma, Journal of Clinical Pathology, vol.63, issue.12, pp.1066-70, 2010.
DOI : 10.1136/jcp.2010.081166

E. Yi, J. Boland, and J. Maleszewski, Correlation of IHC and FISH for ALK Gene Rearrangement in Non-small Cell Lung Carcinoma: IHC Score Algorithm for FISH, Journal of Thoracic Oncology, vol.6, issue.3, pp.459-65, 2011.
DOI : 10.1097/JTO.0b013e318209edb9

T. Chou, Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method, Cancer Research, vol.70, issue.2, pp.440-446, 2010.
DOI : 10.1158/0008-5472.CAN-09-1947

L. Huang, V. Walter, D. Hayes, and M. Onaitis, Hedgehog-GLI Signaling Inhibition Suppresses Tumor Growth in Squamous Lung Cancer, Clinical Cancer Research, vol.20, issue.6, pp.1566-75, 2014.
DOI : 10.1158/1078-0432.CCR-13-2195

J. Sims-mourtada, J. Izzo, J. Ajani, and K. Chao, Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport, Oncogene, vol.7, issue.38, pp.5674-5683, 2007.
DOI : 10.1038/sj.onc.1210356

F. Tian, K. Schrödl, R. Kiefl, R. Huber, and A. Bergner, The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells, Anticancer Res, vol.32, pp.89-94, 2012.

A. Ahmad, M. Maitah, and K. Ginnebaugh, Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs, Journal of Hematology & Oncology, vol.6, issue.1, p.77, 2013.
DOI : 10.1158/1541-7786.MCR-10-0497

D. Yue, H. Li, and C. J. , Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas, Journal of Experimental & Clinical Cancer Research, vol.33, issue.1, p.34, 2014.
DOI : 10.1016/j.ctrv.2010.11.004

M. Agren, P. Kogerman, M. Kleman, M. Wessling, and R. Toftgård, Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site, Gene, vol.330, pp.101-115, 2004.
DOI : 10.1016/j.gene.2004.01.010

M. Ikram, G. Neill, and G. Regl, Gli2 is expressed in normal human epidermidis and BCC and induces Gli1 expression by binding to its promoter

R. Lipinski, J. Gipp, J. Zhang, J. Doles, and W. Bushman, Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling, Experimental Cell Research, vol.312, issue.11
DOI : 10.1016/j.yexcr.2006.02.019

F. Tian, J. Mysliwietz, J. Ellwart, F. Gamarra, R. Huber et al., Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations, Clinical and Experimental Medicine, vol.31, issue.1, pp.25-30, 2012.
DOI : 10.1007/s10238-011-0135-8

H. Li, N. Lui, and T. Cheng, Gli as a Novel Therapeutic Target in Malignant Pleural Mesothelioma, PLoS ONE, vol.18, issue.3, p.57346, 2013.
DOI : 10.1371/journal.pone.0057346.s001

C. Belani, S. Dahlberg, and C. Rudin, Three-arm randomized phase II study of cisplatin and etoposide (CE) versus CE with either vismodegib (V) or cixutumumab (Cx) for patients with extensive stage-small cell lung cancer (ES- SCLC) (ECOG 1508), J Clin Oncol, 2013.