Assessing the antimicrobial activity of polyisoprene-based surfaces.

Abstract : There has been an intense research effort in the last decades in the field of biofouling prevention as it concerns many aspects of everyday life and causes problems to devices, the environment, and human health. Many different antifouling and antimicrobial materials have been developed to struggle against bacteria and other micro- and macro-organism attachment to different surfaces. However the “miracle solution” has still to be found. The research presented here concerns the synthesis of bio-based polymeric materials and the biological tests that showed their antifouling and, at the same time, antibacterial activity. The raw material used for the coating synthesis was natural rubber. The polyisoprene chains were fragmented to obtain oligomers, which had reactive chemical groups at their chain ends, therefore they could be modified to insert polymerizable and biocidal groups. Films were obtained by radical photopolymerization of the natural rubber derived oligomers and their structure was altered, in order to understand the mechanism of attachment inhibition and to increase the efficiency of the anti-biofouling action. The adhesion of three species of pathogenic bacteria and six strains of marine bacteria was studied. The coatings were able to inhibit bacterial attachment by contact, as it was verified that no detectable leaching of toxic molecules occurred.
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Submitted on : Monday, December 21, 2015 - 11:19:21 AM
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Badawy Hope, Jérôme Brunellière, Veryaskina Marina, Guillaume Brotons, Sophie Sablé, et al.. Assessing the antimicrobial activity of polyisoprene-based surfaces.. International Journal of Molecular Sciences, MDPI, 2015, ⟨10.3390/ijms16034392⟩. ⟨hal-01247079⟩



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