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Communication Dans Un Congrès Année : 2011

An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays

Julie Aubert
Olivier Sandra

Résumé

In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and largescale microarrays in CBA×DBA/2 and CBA×BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.

Dates et versions

hal-01239519 , version 1 (07-12-2015)

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Gérard Chaouat, Nathalie Rodde, Marie Petitbarat, Roberta Bulla, Mona Rahmati, et al.. An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays. 7. International Workshop on Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia, European Society for Reproductive Immunology (ESRI). POL., Aug 2010, Tioman Island, Malaysia. ⟨10.1016/j.jri.2010.12.006⟩. ⟨hal-01239519⟩
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