C. Field, M. Behrenfeld, J. Randerson, and P. Falkowski, Primary Production of the Biosphere: Integrating Terrestrial and Oceanic Components, Science, vol.281, issue.5374, pp.281237-240, 1998.
DOI : 10.1126/science.281.5374.237

M. Behrenfeld, O. Malley, R. Siegel, D. Mcclain, C. Sarmiento et al., Climate-driven trends in contemporary ocean productivity, Nature, vol.308, issue.7120, pp.444752-755, 2006.
DOI : 10.1038/nature05317

M. Steinacher, F. Joos, T. Frölicher, L. Bopp, P. Cadule et al., Projected 21st century decrease in marine productivity: a multi-model analysis, Biogeosciences, vol.7, issue.3, pp.979-1005, 2010.
DOI : 10.5194/bg-7-979-2010

S. Seitzinger and C. Kroeze, Global distribution of nitrous oxide production and N inputs in freshwater and coastal marine ecosystems, Global Biogeochemical Cycles, vol.34, issue.4
DOI : 10.1029/97GB03657

A. Bakun, D. Field, A. Redondo-rodriguez, and S. Weeks, Greenhouse gas, upwelling-favorable winds, and the future of coastal ocean upwelling ecosystems, Global Change Biology, vol.5, issue.(13), pp.1213-1228, 2010.
DOI : 10.1111/j.1365-2486.2009.02094.x

G. Felsner, M. Sommer, N. Gruenheit, F. Hempel, D. Moog et al., ERAD Components in Organisms with Complex Red Plastids Suggest Recruitment of a Preexisting Protein Transport Pathway for the Periplastid Membrane, Genome Biology and Evolution, vol.3, issue.0, p.140, 2011.
DOI : 10.1093/gbe/evq074

B. Read, J. Kegel, M. Klute, A. Kuo, S. Lefebvre et al., The Emiliania huxleyi Genome annotation consortium, Dacks JB, et al: Pan genome of the phytoplankton Emiliania underpins its global distribution, Nature, vol.2013, issue.7457, pp.499209-213

E. Paasche, A review of the coccolithophorid Emiliania huxleyi (Prymnesiophyceae), with particular reference to growth, coccolith formation, and calcification-photosynthesis interactions, Phycologia, vol.40, issue.6, pp.503-529, 2002.
DOI : 10.2216/i0031-8884-40-6-503.1

B. Rost, U. Riebesell, H. Thierstein, and E. Young, Coccolithophores and the biological pump: responses to environmental changes, Coccolithophores -From Molecular Processes to Global Impact, pp.76-99, 2004.
DOI : 10.1007/978-3-662-06278-4_5

J. Kegel, U. John, K. Valentin, and S. Frickenhaus, Genome Variations Associated with Viral Susceptibility and Calcification in Emiliania huxleyi, PLoS ONE, vol.22, issue.11, p.80684
DOI : 10.1371/journal.pone.0080684.s005

J. Raven and K. Crawfurd, Environmental controls on coccolithophore calcification, Marine Ecology Progress Series, vol.470, pp.137-166, 2012.
DOI : 10.3354/meps09993

C. Borchard, A. Borges, N. Händel, and A. Engel, Biogeochemical response of Emiliania huxleyi (PML B92/11) to elevated CO2 and temperature under phosphorous limitation: A chemostat study, Journal of Experimental Marine Biology and Ecology, vol.410, pp.61-71, 2011.
DOI : 10.1016/j.jembe.2011.10.004

N. Van-oostende, T. Moerdijk-poortvliet, H. Boschker, W. Vyverman, and K. Sabbe, and formation of transparent exopolymer particles depend on algal life cycle and bacterial activity, Environmental Microbiology, vol.7, issue.5, pp.1514-1531, 2013.
DOI : 10.1111/j.1462-2920.2012.02873.x

J. Green, P. Course, and G. Tarran, The life-cycle of Emiliania huxleyi: A brief review and a study of relative ploidy levels analysed by flow cytometry, Journal of Marine Systems, vol.9, issue.1-2, pp.33-44, 1996.
DOI : 10.1016/0924-7963(96)00014-0

V. Dassow, P. Ogata, H. Probert, I. Wincker, P. et al., Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell, Genome Biol, issue.10, pp.10-114, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01258261

M. Frada, I. Probert, M. Allen, W. Wilson, D. Vargas et al., The "Cheshire Cat" escape strategy of the coccolithophore Emiliania huxleyi in response to viral infection, Proceedings of the National Academy of Sciences, vol.105, issue.41, pp.15944-15949, 2008.
DOI : 10.1073/pnas.0807707105

A. Houdan, I. Probert, K. Van-lenning, and S. Lefebvre, Comparison of photosynthetic responses in diploid and haploid life-cycle phases of Emiliania huxleyi (Prymnesiophyceae), Marine Ecology Progress Series, vol.292, pp.139-146, 2005.
DOI : 10.3354/meps292139

S. Rokitta, D. Nooijer, L. Trimborn, S. , D. Vargas et al., TRANSCRIPTOME ANALYSES REVEAL DIFFERENTIAL GENE EXPRESSION PATTERNS BETWEEN THE LIFE-CYCLE STAGES OF EMILIANIA HUXLEYI (HAPTOPHYTA) AND REFLECT SPECIALIZATION TO DIFFERENT ECOLOGICAL NICHES1, Journal of Phycology, vol.8, issue.4, pp.829-838, 2011.
DOI : 10.1111/j.1529-8817.2011.01014.x
URL : https://hal.archives-ouvertes.fr/hal-01258249

A. Barton, S. Dutkiewicz, G. Flierl, J. Bragg, and M. Follows, Patterns of Diversity in Marine Phytoplankton, Science, vol.327, issue.5972, pp.1509-1511, 2010.
DOI : 10.1126/science.1184961

M. Follows, S. Dutkiewicz, S. Grant, and S. Chisholm, Emergent Biogeography of Microbial Communities in a Model Ocean, Science, vol.315, issue.5820, pp.3151843-1846, 2007.
DOI : 10.1126/science.1138544

Y. Xu, J. Boucher, and F. Morel, EXPRESSION AND DIVERSITY OF ALKALINE PHOSPHATASE EHAP1 IN EMILIANIA HUXLEYI (PRYMNESIOPHYCEAE)1, Journal of Phycology, vol.42, issue.1, pp.85-92, 2010.
DOI : 10.1111/j.1529-8817.2009.00788.x

D. Wolf-gladrow, R. Zeebe, C. Klaas, A. Koertzinger, and A. Dickson, Total alkalinity: The explicit conservative expression and its application to biogeochemical processes, Marine Chemistry, vol.106, issue.1-2, pp.287-300, 2007.
DOI : 10.1016/j.marchem.2007.01.006

S. Rokitta, U. John, and B. Rost, Ocean Acidification Affects Redox-Balance and Ion-Homeostasis in the Life-Cycle Stages of Emiliania huxleyi, PLoS ONE, vol.158, issue.3, p.52212
DOI : 10.1371/journal.pone.0052212.s002

S. Dyhrman, S. Haley, S. Birkeland, L. Wurch, M. Cipriano et al., Long Serial Analysis of Gene Expression for Gene Discovery and Transcriptome Profiling in the Widespread Marine Coccolithophore Emiliania huxleyi, Applied and Environmental Microbiology, vol.72, issue.1, pp.252-260, 2006.
DOI : 10.1128/AEM.72.1.252-260.2006

R. Willows and J. Hoober, Chlorophyll Synthesis In The Structure and Function of Plastids, pp.295-313, 2006.

B. Mckew, S. Lefebvre, E. Achterberg, G. Metodieva, C. Raines et al., CCMP 1516 to extremes of light is highly targeted, New Phytologist, vol.145, issue.1, pp.61-73, 2013.
DOI : 10.1111/nph.12352

I. Benner and U. Passow, Utilization of organic nutrients by coccolithophores, Marine Ecology Progress Series, vol.404, pp.21-29, 2010.
DOI : 10.3354/meps08474

M. Rouco, O. Branson, M. Lebrato, and M. Iglesias-rodriguez, The effect of nitrate and phosphate availability on Emiliania huxleyi (NZEH) physiology under different CO 2 scenarios, p.155

A. Allen, C. Dupont, M. Obornik, A. Horak, A. Nunes-nesi et al., Evolution and metabolic significance of the urea cycle in photosynthetic diatoms, Nature, vol.24, issue.7346, pp.473203-207, 2011.
DOI : 10.1038/nature10074

N. Hockin, T. Mock, F. Mulholland, S. Kopriva, and G. Malin, The Response of Diatom Central Carbon Metabolism to Nitrogen Starvation Is Different from That of Green Algae and Higher Plants, PLANT PHYSIOLOGY, vol.158, issue.1, pp.299-312
DOI : 10.1104/pp.111.184333

S. Bender, C. Durkin, C. Berthiaume, R. Morales, and E. Armbrust, Transcriptional responses of three model diatoms to nitrate limitation of growth, Frontiers in Marine Science, vol.27, p.3, 2014.
DOI : 10.1111/j.0022-3646.1991.00014.x

S. Dagenais-bellefeuille and D. Morse, Putting the N in dinoflagellates, Frontiers in Microbiology, vol.4, p.369, 2013.
DOI : 10.3389/fmicb.2013.00369

R. Alcázar, T. Altabella, F. Marco, C. Bortolotti, M. Reymond et al., Polyamines: molecules with regulatory functions in plant abiotic stress tolerance, Planta, vol.145, issue.6, pp.2311237-1249, 2010.
DOI : 10.1007/s00425-010-1130-0

L. Szabados and A. Savouré, Proline: a multifunctional amino acid, Trends in Plant Science, vol.15, issue.2, pp.89-97
DOI : 10.1016/j.tplants.2009.11.009

A. Altman and N. Levin, Interactions of polyamines and nitrogen nutrition in plants, Physiologia Plantarum, vol.18, issue.3, pp.653-658, 1993.
DOI : 10.1146/annurev.biochem.53.1.749

G. Miller, A. Honig, H. Stein, N. Suzuki, R. Mittler et al., Unraveling ?1-pyrroline-5-carboxylate-proline cycle in plants by uncoupled expression of proline oxidation enzymes, J Biol Chem, issue.39, pp.28426482-26492, 2009.

J. Pandhare, S. Donald, S. Cooper, and J. Phang, Regulation and function of proline oxidase under nutrient stress, Journal of Cellular Biochemistry, vol.263, issue.4, pp.759-768, 2009.
DOI : 10.1002/jcb.22174

Y. Liu, G. Borchert, S. Donald, B. Diwan, M. Anver et al., Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers, Cancer Research, vol.69, issue.16, pp.696414-6422, 2009.
DOI : 10.1158/0008-5472.CAN-09-1223

S. Natarajan, W. Zhu, X. Liang, L. Zhang, A. Demers et al., Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death, Free Radical Biology and Medicine, vol.53, issue.5, pp.531181-1191
DOI : 10.1016/j.freeradbiomed.2012.07.002

C. Maurin and L. Gal, Isoforms of Glutamine Synthetase in the Marine Coccolithophorid Emiliania huxleyi (Prymnesiophyceae), Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol.118, issue.4, pp.903-912, 1997.
DOI : 10.1016/S0305-0491(97)00279-4

C. Maurin, L. Gal, and Y. , Glutamine synthetase in the marine coccolithophorid Emiliania huxleyi (Prymnesiophyceae): regulation of activity in relation to light and nitrogen availability, Plant Science, vol.122, issue.1, pp.61-69, 1997.
DOI : 10.1016/S0168-9452(96)04539-6

H. Huppe and D. Turpin, Integration of Carbon and Nitrogen Metabolism in Plant and Algal Cells, Annual Review of Plant Physiology and Plant Molecular Biology, vol.45, issue.1, pp.577-607, 1994.
DOI : 10.1146/annurev.pp.45.060194.003045

I. Benner, R. Diner, S. Lefebvre, D. Li, T. Komada et al., Emiliania huxleyi increases calcification but not expression of http://www.biomedcentral.com/1471-2164/15/1051 calcification-related genes in long-term exposure to elevated temperature and pCO 2, Philos Trans R Soc B Biol Sci, vol.2013, p.3681627, 1627.

M. Eltgroth, R. Watwood, and G. Wolfe, PRODUCTION AND CELLULAR LOCALIZATION OF NEUTRAL LONG-CHAIN LIPIDS IN THE HAPTOPHYTE ALGAE ISOCHRYSIS GALBANA AND EMILIANIA HUXLEYI1, Journal of Phycology, vol.32, issue.5, pp.1000-1009, 2005.
DOI : 10.1016/S0005-2736(00)00294-7

A. Benthien, I. Zondervan, A. Engel, J. Hefter, A. Terbrüggen et al., Carbon isotopic fractionation during a mesocosm bloom experiment dominated by Emiliania huxleyi: Effects of CO2 concentration and primary production, Geochimica et Cosmochimica Acta, vol.71, issue.6, pp.711528-1541, 2007.
DOI : 10.1016/j.gca.2006.12.015

M. Palmucci, S. Ratti, and M. Giordano, ECOLOGICAL AND EVOLUTIONARY IMPLICATIONS OF CARBON ALLOCATION IN MARINE PHYTOPLANKTON AS A FUNCTION OF NITROGEN AVAILABILITY: A FOURIER TRANSFORM INFRARED SPECTROSCOPY APPROACH1, Journal of Phycology, vol.39, issue.2, pp.313-323, 2011.
DOI : 10.1111/j.1529-8817.2011.00963.x

J. Danne, S. Gornik, J. Macrae, M. Mcconville, and R. Waller, Alveolate Mitochondrial Metabolic Evolution: Dinoflagellates Force Reassessment of the Role of Parasitism as a Driver of Change in Apicomplexans, Molecular Biology and Evolution, vol.30, issue.1, pp.123-139
DOI : 10.1093/molbev/mss205

D. Molenaar, M. Van-der-rest, and S. Petrovi?, Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum, European Journal of Biochemistry, vol.254, issue.2, pp.395-403, 1998.
DOI : 10.1046/j.1432-1327.1998.2540395.x

B. Kather, K. Stingl, M. Van-der-rest, K. Altendorf, and D. Molenaar, Another Unusual Type of Citric Acid Cycle Enzyme in Helicobacter pylori: the Malate:Quinone Oxidoreductase, Journal of Bacteriology, vol.182, issue.11, pp.1823204-3209, 2000.
DOI : 10.1128/JB.182.11.3204-3209.2000

A. Kaffes, S. Thoms, S. Trimborn, B. Rost, G. Langer et al., Carbon and nitrogen fluxes in the marine coccolithophore Emiliania huxleyi grown under different nitrate concentrations, Journal of Experimental Marine Biology and Ecology, vol.393, issue.1-2, pp.1-8, 2010.
DOI : 10.1016/j.jembe.2010.06.004

N. Poulsen and N. Kröger, A new molecular tool for transgenic diatoms, FEBS Journal, vol.22, issue.13, pp.3413-3423, 2005.
DOI : 10.1111/j.1742-4658.2005.04760.x

P. Quinn, R. Bowers, X. Zhan, T. Wahlund, M. Fanelli et al., cDNA Microarrays as a Tool for Identification of Biomineralization Proteins in the Coccolithophorid Emiliania huxleyi (Haptophyta), Applied and Environmental Microbiology, vol.72, issue.8
DOI : 10.1128/AEM.00343-06

J. Prihoda, A. Tanaka, D. Paula, W. Allen, J. Tirichine et al., Chloroplast-mitochondria cross-talk in diatoms, Journal of Experimental Botany, vol.63, issue.4, pp.1543-1557
DOI : 10.1093/jxb/err441

J. Kegel, M. Blaxter, M. Allen, K. Metfies, W. Wilson et al., (Haptophyceae) and EhV-86 deduced from combined analysis of expressed sequence tags and microarrays, European Journal of Phycology, vol.38, issue.1, pp.1-12, 2010.
DOI : 10.1017/S002531540200560X

M. Bochenek, G. Etherington, A. Koprivova, S. Mugford, T. Bell et al., Transcriptome analysis of the sulfate deficiency response in the marine microalga Emiliania huxleyi, New Phytol, issue.3, pp.199650-662, 2013.

A. Dickson, An exact definition of total alkalinity and a procedure for the estimation of alkalinity and total inorganic carbon from titration data. Deep Sea Res Part I-Oceanograp Res Pap, pp.609-623, 1981.

M. Stoll, K. Bakker, G. Nobbe, and R. Haese, Continuous-Flow Analysis of Dissolved Inorganic Carbon Content in Seawater, Analytical Chemistry, vol.73, issue.17, pp.734111-4116, 2001.
DOI : 10.1021/ac010303r

D. Pierrot, E. Lewis, and D. Wallace, MS Excel program developed for CO 2 system calculations, Carbon Dioxide Information Analysis Center, Oak Ridge National Laboratory (ORNL). Oak Ridge, 2006.

A. Dickson and F. Millero, A comparison of the equilibrium constants for the dissociation of carbonic acid in seawater media. Deep Sea Res I, pp.1733-1743, 1987.

A. Dickson, Standard potential of the reaction: , and and the standard acidity constant of the ion HSO4??? in synthetic sea water from 273.15 to 318.15 K, The Journal of Chemical Thermodynamics, vol.22, issue.2, pp.113-127, 1990.
DOI : 10.1016/0021-9614(90)90074-Z

H. Stoll, R. Encinar, J. , I. G. Alonso, J. Rosenthal et al., A first look at paleotemperature prospects from Mg in coccolith carbonate: Cleaning techniques and culture measurements, Geochemistry, Geophysics, Geosystems, vol.22, issue.2, p.1047, 2001.
DOI : 10.1029/2000GC000144