Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Anne Fages 1, 2 Talita Duarte-Salles 3 Magdalena Stepien 3 Pietro Ferrari 4 Veronika Fedirko 5 Clément Pontoizeau 6 Antonia Trichopoulou 7 Krasimira Aleksandrova 8 Anne Tjønneland 9 Anja Olsen 10 Françoise Clavel-Chapelon 11 Marie-Christine Boutron-Ruault 11, 12 Gianluca Severi Rudolf Kaaks 13 Tilman Kuhn 14 Anna Floegel 15 Heiner Boeing 16 Pagona Lagiou 7, 17 Christina Bamia 18 Dimitrios Trichopoulos 7 Domenico Palli 19 Valeria Pala 20 Salvatore Panico 21 Rosario Tumino 22 Paolo Vineis 23 H. Bas Bueno-De-Mesquita 24 Petra H. Peeters 25, 26 Elisabete Weiderpass 27, 28, 29 Antonio Agudo 30 Esther Molina-Montes 31, 32 José María Huerta 33, 34 Eva Ardanaz 32, 35 Miren Dorronsoro 36 Klas Sjöberg 37 Bodil Ohlsson Kay-Tee Khaw Nick Wareham 38 Ruth C. Travis 39 Julie A. Schmidt 40 Amanda Cross Marc Gunter 41 Elio Riboli 42 Augustin Scalbert 43 Isabelle Romieu 44 Benedicte Elena-Herrmann 2 Mazda Jenab 5
2 NMR Methods for Metabolism - Methodes RMN en métabolomique
ISA - Institut des Sciences Analytiques
37 Volvo
Abstract : Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer.
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Submitted on : Thursday, November 26, 2015 - 5:00:03 PM
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Anne Fages, Talita Duarte-Salles, Magdalena Stepien, Pietro Ferrari, Veronika Fedirko, et al.. Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort. BMC Medicine, BioMed Central, 2015, 13, pp.Article number: 242. ⟨10.1186/s12916-015-0462-9⟩. ⟨hal-01234339⟩



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