First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

Gérard Jaouen (1) , Siden Top (1) , Anne Vessieres (1) , Pascal Pigeon (1) , Guy Leclercq (2) , Ionna Laios (2)

1 CBCM - Chimie et biochimie des complexes moléculaires
2 Laboratoire de Cancérologie Mammaire [Bruxelles]

A route to the organometallic complex 8 is described, along with a study of its antiproliferative effects on breast cancer cell lines; in the examples studied, 8 behaves in a very similar manner to tamoxifen, suggesting new possibilities for applications in organometallic chemistry.

Domaines: Chimie

Gérard Jaouen, Siden Top, Anne Vessieres, Pascal Pigeon, Guy Leclercq, et al.. First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects. Chemical Communications, 2001, 4, pp.383-384. ⟨10.1039/b009553m⟩. ⟨hal-01230409⟩