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Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Abstract : A series of new 1-[di-(4-R-phenyl)-methylidenyl)]-[3]ferrocenophanes, where R = OH, NH2, NHAc, and the phenyl substitution is mixed or identical, are highly antiproliferative against MDA-MB-231 and PC-3 cancer cells, with IC50 values ranging from 0 05-5 6 mu M on MDA-M B-231 and 0 02-12 5 mu M on PC-3
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Meral Görmen, Pascal Pigeon, Siden Top, Anne Vessières, Marie-Aude Plamont, et al.. Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines. MedChemComm, 2010, 1 (2), pp.149-151. ⟨10.1039/c0md00026d⟩. ⟨hal-01230393⟩

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