Skip to Main content Skip to Navigation
New interface
Journal articles

Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells

Abstract : Recent results suggest that [3]ferrocenophane may be an interesting motif in the development of cytotoxic anti-cancer agents. We here report the synthesis of three such compounds based on the 1[(p-R-phenyl)-phenyl-methylidenyl)]-[3]ferrocenophane skeleton with R=OH, NH(2) and NHC(O)CH(3) substitution on one of the phenyl rings. Cytotoxicity studies show that these compounds are up to four times more powerful against hormone-independent breast cancer cells than their corresponding ferrocene analogs. (C) 2009 Elsevier Ltd. All rights reserved.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-01230391
Contributor : Gestionnaire HAL-UPMC Connect in order to contact the contributor
Submitted on : Wednesday, January 4, 2017 - 11:34:42 AM
Last modification on : Tuesday, January 25, 2022 - 8:22:02 AM
Long-term archiving on: : Wednesday, April 5, 2017 - 1:44:38 PM

File

pub821.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Meral Görmen, Damian Plazuk, Pascal Pigeon, Elisabeth A. Hillard, Marie-Aude Plamont, et al.. Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells. Tetrahedron Letters, 2010, 51 (1), pp.118-120. ⟨10.1016/j.tetlet.2009.10.102⟩. ⟨hal-01230391⟩

Share

Metrics

Record views

125

Files downloads

397