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Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells

Abstract : Recent results suggest that [3]ferrocenophane may be an interesting motif in the development of cytotoxic anti-cancer agents. We here report the synthesis of three such compounds based on the 1[(p-R-phenyl)-phenyl-methylidenyl)]-[3]ferrocenophane skeleton with R=OH, NH(2) and NHC(O)CH(3) substitution on one of the phenyl rings. Cytotoxicity studies show that these compounds are up to four times more powerful against hormone-independent breast cancer cells than their corresponding ferrocene analogs. (C) 2009 Elsevier Ltd. All rights reserved.
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Submitted on : Wednesday, January 4, 2017 - 11:34:42 AM
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Meral Görmen, Damian Plazuk, Pascal Pigeon, Elisabeth A. Hillard, Marie-Aude Plamont, et al.. Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells. Tetrahedron Letters, 2010, 51 (1), pp.118-120. ⟨10.1016/j.tetlet.2009.10.102⟩. ⟨hal-01230391⟩



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