]. B. Bertrand and A. Casini, A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds, Dalton Trans., vol.40, issue.11, pp.4209-4219
DOI : 10.1039/c1dt10636h

]. B. Biersack and R. Schobert, Metallodrug Conjugates with Steroids and Selective Estrogen Receptor Modulators (SERM), Current Medicinal Chemistry, vol.16, issue.18, pp.2324-2337, 2009.
DOI : 10.2174/092986709788453050

R. Alberto, The particular role of radiopharmacy within bioorganometallic chemistry, Journal of Organometallic Chemistry, vol.692, issue.6, pp.1179-1186, 2007.
DOI : 10.1016/j.jorganchem.2006.11.019

N. Metzler-nolte and M. , Salmain in Ferrocenes: Ligands, Materials and Biomolecules, pp.499-639, 2008.

G. Jaouen and S. , Top in Advances in Organometallic Chemistry and Catalysis The Silver/Gold Jubilee International Conference on Organometallic Chemistry Celebration Book, pp.563-580

A. Nguyen, A. Vessières, E. A. Hillard, S. Top, P. Pigeon et al., Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer, CHIMIA International Journal for Chemistry, vol.61, issue.11, pp.716-724, 2007.
DOI : 10.2533/chimia.2007.716
URL : https://hal.archives-ouvertes.fr/hal-01230400

A. Vessières, S. Top, P. Pigeon, E. A. Hillard, L. Boubeker et al., Modification of the Estrogenic Properties of Diphenols by the Incorporation of Ferrocene. Generation of Antiproliferative Effects in Vitro, Journal of Medicinal Chemistry, vol.48, issue.12, pp.3937-3940, 2005.
DOI : 10.1021/jm050251o

J. B. Heilmann, E. A. Hillard, M. Plamont, P. Pigeon, M. Bolte et al., Ferrocenyl compounds possessing protected phenol and thiophenol groups: Synthesis, X-ray structure, and in vitro biological effects against breast cancer, Journal of Organometallic Chemistry, vol.693, issue.8-9, pp.1716-1722, 2008.
DOI : 10.1016/j.jorganchem.2007.12.011
URL : https://hal.archives-ouvertes.fr/hal-01230397

B. Testa and S. D. Kramer, The Biochemistry of Drug Metabolism - An Introduction, Chemistry & Biodiversity, vol.6, issue.5, pp.591-684, 2009.
DOI : 10.1002/cbdv.200900022

D. Yao, F. Zhang, L. Yu, Y. Yang, R. B. Van-breemen et al., -Quinones, Chemical Research in Toxicology, vol.14, issue.12, pp.1643-1653, 2001.
DOI : 10.1021/tx010137i

E. A. Hillard, A. Vessières, L. Thouin, G. Jaouen, and C. Amatore, Ferrocene-Mediated Proton-Coupled Electron Transfer in a Series of Ferrocifen-Type Breast-Cancer Drug Candidates, Angewandte Chemie International Edition, vol.44, issue.2, pp.285-290, 2006.
DOI : 10.1016/0360-3016(89)90914-0

P. Messina, E. Labbé, O. Buriez, E. A. Hillard, A. Vessières et al., Deciphering the Activation Sequence of Ferrociphenol Anticancer Drug Candidates, Chemistry - A European Journal, vol.28, issue.21, pp.6581-6587, 2012.
DOI : 10.1021/bi00429a028

D. Hamels, P. M. Dansette, E. A. Hillard, S. Top, A. Vessières et al., Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols, Angewandte Chemie International Edition, vol.36, issue.48, pp.9124-9126, 2009.
DOI : 10.1039/b705030e

A. Citta, A. Folda, A. Bindoli, P. Pigeon, S. Top et al., Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells, Journal of Medicinal Chemistry, vol.57, issue.21, pp.8849-8859, 2014.
DOI : 10.1021/jm5013165
URL : https://hal.archives-ouvertes.fr/hal-01230376

D. J. Boocock, J. L. Maggs, I. N. White, and B. K. Park, ??-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro, Carcinogenesis, vol.20, issue.1, pp.153-160, 1999.
DOI : 10.1016/S0140-6736(97)11423-4

S. Y. Kim, N. Suzuki, L. Y. Santosh, R. Rieger, and S. Shibutani, ??-Hydroxylation of Tamoxifen and Toremifene by Human and Rat Cytochrome P450 3A Subfamily Enzymes, Chemical Research in Toxicology, vol.16, issue.9, pp.1138-1144, 2003.
DOI : 10.1021/tx0300131

L. M. Notley, K. H. Crewe, P. J. Taylor, M. S. Lennard, and E. M. Gillam, Characterization of the Human Cytochrome P450 Forms Involved in Metabolism of Tamoxifen to Its ??-Hydroxy and ??,4-Dihydroxy Derivatives, Chemical Research in Toxicology, vol.18, issue.10, pp.1611-1618, 2005.
DOI : 10.1021/tx050140s

L. M. Notley, W. C. De, R. M. Wunsch, R. G. Lancaster, and E. M. Gillam, Bioactivation of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes, Chemical Research in Toxicology, vol.15, issue.5, pp.614-622, 2002.
DOI : 10.1021/tx0100439

T. S. Dowers, Z. H. Qin, G. R. Thatcher, and J. L. Bolton, Bioactivation of Selective Estrogen Receptor Modulators (SERMs), Chemical Research in Toxicology, vol.19, issue.9, pp.1125-1137, 2006.
DOI : 10.1021/tx060126v

P. W. Fan, F. Zhang, and J. L. Bolton, 4-Hydroxylated Metabolites of the Antiestrogens Tamoxifen and Toremifene Are Metabolized to Unusually Stable Quinone Methides, Chemical Research in Toxicology, vol.13, issue.1, pp.45-52, 2000.
DOI : 10.1021/tx990144v

M. M. Marques and F. A. Beland, Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide, Carcinogenesis, vol.18, issue.10, pp.1949-1954, 1997.
DOI : 10.1093/carcin/18.10.1949

V. P. Androutsopoulos, K. Ruparelia, R. R. Arroo, A. M. Tsatsakis, and D. A. Spandidos, CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells, Toxicology, vol.264, issue.3, pp.162-170, 2009.
DOI : 10.1016/j.tox.2009.07.023

G. M. Sheldrick, SADABS, Program for scaling and correction of area detector data, 1997.

R. H. Blessing, An empirical correction for absorption anisotropy, Acta Crystallographica Section A Foundations of Crystallography, vol.51, issue.1, pp.33-38, 1995.
DOI : 10.1107/S0108767394005726

P. W. Betteridge, J. R. Carruthers, R. I. Cooper, K. Prout, and D. J. Watkin, version 12: software for guided crystal structure analysis, Journal of Applied Crystallography, vol.36, issue.6, pp.1487-1487, 2003.
DOI : 10.1107/S0021889803021800

P. Kremers, P. Beaune, T. Cresteil, J. De-graeve, S. Columelli et al., Cytochrome P-450 Monooxygenase Activities in Human and Rat Liver Microsomes, European Journal of Biochemistry, vol.35, issue.3, pp.599-606, 1981.
DOI : 10.1016/0022-4731(76)90204-1