Biomimetic microfluidic neuron for hybrid experiments

Timothée Levi (1) , Agnès Mita-Tixier (1) , Bertrand David Segard (1) , Toshiyoshi Hiroshi (1) , H. Fujita (1) , T. Fujii (1)

1 LIMMS - Laboratory for Integrated Micro Mechatronics Systems

This paper reports a new way to explore in the neuromorphic engineering, the biomimetic artificial neuron using microfluidic techniques. This device is able to mimic the electrical activity of one biological neuron. Usually these artificial neurons are made in Silicon but this device could replace the electronic one and solve most of the issues of biocompatibility. This PDMS device is composed of two chambers for intra and extra-cellular modelling, different PDMS channels, selective permeable membrane for positive ionic exchange, quake valves and electrodes for recording the membrane potential. We obtain an electrical membrane potential similar to the biological neuron.

Domaines: Ingénierie biomédicale

Timothée Levi, Agnès Mita-Tixier, Bertrand David Segard, Toshiyoshi Hiroshi, H. Fujita, et al.. Biomimetic microfluidic neuron for hybrid experiments. MicroTAS 2015, Oct 2015, Gyeongju, South Korea. ⟨hal-01227659⟩