Simulation-Based Evaluation of the Performances of an Algorithm for Detecting Abnormal Disease-Related Features in Cattle Mortality Records

Jean-Baptiste Perrin (1, 2) , Benoît Durand (3) , Emilie Gay (1) , Christian Ducrot (2) , Pascal Hendrikx (4) , Didier Calavas (1) , Viviane Hénaux (1)

1 Laboratoire de Lyon [ANSES]
2 UR EpiA - Unité de Recherche d'Épidémiologie Animale
3 Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie
4 UCAS - Direction des Laboratoires

We performed a simulation study to evaluate the performances of an anomaly detection algorithm considered in the frame of an automated surveillance system of cattle mortality. The method consisted in a combination of temporal regression and spatial cluster detection which allows identifying, for a given week, clusters of spatial units showing an excess of deaths in comparison with their own historical fluctuations. First, we simulated 1,000 outbreaks of a disease causing extra deaths in the French cattle population (about 200,000 herds and 20 million cattle) according to a model mimicking the spreading patterns of an infectious disease and injected these disease-related extra deaths in an authentic mortality dataset, spanning from January 2005 to January 2010. Second, we applied our algorithm on each of the 1,000 semi-synthetic datasets to identify clusters of spatial units showing an excess of deaths considering their own historical fluctuations. Third, we verified if the clusters identified by the algorithm did contain simulated extra deaths in order to evaluate the ability of the algorithm to identify unusual mortality clusters caused by an outbreak. Among the 1,000 simulations, the median duration of simulated outbreaks was 8 weeks, with a median number of 5,627 simulated deaths and 441 infected herds. Within the 12-week trial period, 73% of the simulated outbreaks were detected, with a median timeliness of 1 week, and a mean of 1.4 weeks. The proportion of outbreak weeks flagged by an alarm was 61% (i.e. sensitivity) whereas one in three alarms was a true alarm (i.e. positive predictive value). The performances of the detection algorithm were evaluated for alternative combination of epidemiologic parameters. The results of our study confirmed that in certain conditions automated algorithms could help identifying abnormal cattle mortality increases possibly related to unidentified health events.

Mots clés: surveillance system; cattle; death rates; infectious diseases; veterinary epidemiology; veterinary diseases

Domaines: Médecine vétérinaire et santé animale; Maladies infectieuses; Santé publique et épidémiologie

Jean-Baptiste Perrin, Benoît Durand, Emilie Gay, Christian Ducrot, Pascal Hendrikx, et al.. Simulation-Based Evaluation of the Performances of an Algorithm for Detecting Abnormal Disease-Related Features in Cattle Mortality Records. PLoS ONE, 2015, 10 (11), pp.e0141273. ⟨10.1371/journal.pone.0141273⟩. ⟨hal-01226770⟩