Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Progress in Neurobiology Année : 2015

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

Susan H. Fox
  • Fonction : Auteur
  • PersonId : 958961

Résumé

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.
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Dates et versions

hal-01214531 , version 1 (12-10-2015)

Identifiants

  • HAL Id : hal-01214531 , version 1
  • PUBMED : 26209473

Citer

Matthieu F. Bastide, Wassilios G. Meissner, Barbara Picconi, Stefania Fasano, Pierre-Olivier Fernagut, et al.. Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.. Progress in Neurobiology, 2015. ⟨hal-01214531⟩

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