Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

Abstract : Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.
Type de document :
Article dans une revue
Progress in Neurobiology, Elsevier, 2015, 〈10.1016〉
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01214531
Contributeur : Chantal Guerin <>
Soumis le : lundi 12 octobre 2015 - 14:51:43
Dernière modification le : jeudi 11 janvier 2018 - 06:25:42

Identifiants

Collections

Citation

Matthieu F. Bastide, Wassilios Meissner, Barbara Picconi, Stefania Fasano, Pierre-Olivier Fernagut, et al.. Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.. Progress in Neurobiology, Elsevier, 2015, 〈10.1016〉. 〈hal-01214531〉

Partager

Métriques

Consultations de la notice

134