S. Bagga, J. Bracht, S. Hunter, K. Massirer, J. Holtz et al., Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation, Cell, vol.122, issue.4, pp.553-563, 2005.
DOI : 10.1016/j.cell.2005.07.031

C. Benoit, H. Ould-hamouda, D. Crepin, A. Gertler, L. Amar et al., Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs, Journal of Endocrinology, vol.218, issue.1, pp.35-47, 2013.
DOI : 10.1530/JOE-12-0561
URL : https://hal.archives-ouvertes.fr/hal-00913357

E. D. Berglund, C. R. Vianna, J. Donato, . Jr, M. H. Kim et al., Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice, Journal of Clinical Investigation, vol.122, issue.3, pp.1000-1009, 2012.
DOI : 10.1172/JCI59816DS1

R. B. Ceddia, W. N. William, . Jr, A. R. Carpinelli, C. et al., Modulation of insulin secretion by leptin, General Pharmacology: The Vascular System, vol.32, issue.2, pp.233-237, 1999.
DOI : 10.1016/S0306-3623(98)00185-2

A. S. Chen, D. J. Marsh, M. E. Trumbauer, E. G. Frazier, X. M. Guan et al., Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass, Nat. Genet, vol.26, pp.97-102, 1038.

H. R. Chiang, L. W. Schoenfeld, J. G. Ruby, V. C. Auyeung, N. Spies et al., Mammalian microRNAs: experimental evaluation of novel and previously annotated genes, Genes & Development, vol.24, issue.10, pp.992-1009, 2010.
DOI : 10.1101/gad.1884710

M. A. Cowley, J. L. Smart, M. Rubinstein, M. G. Cerdán, S. Diano et al., Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus, Nature, vol.411, issue.6836, pp.480-484, 1038.
DOI : 10.1038/35078085

D. Crépin, Y. Benomar, L. Riffault, H. Amine, A. Gertler et al., The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment, Molecular and Cellular Endocrinology, vol.384, issue.1-2, pp.1-11, 2014.
DOI : 10.1016/j.mce.2013.12.016

Q. Gao, M. J. Wolfgang, S. Neschen, K. Morino, T. L. Horvath et al., Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation, Proceedings of the National Academy of Sciences, vol.101, issue.13, pp.4661-4666, 2004.
DOI : 10.1073/pnas.0303992101

C. Girardet, M. S. Bonnet, R. Jdir, M. Sadoud, S. Thirion et al., Central Inflammation and Sickness-Like Behavior Induced by the Food Contaminant Deoxynivalenol: A PGE2-Independent Mechanism, Toxicological Sciences, vol.124, issue.1, pp.179-191, 1210.
DOI : 10.1093/toxsci/kfr219

S. Herzer, A. Silahtaroglu, and B. Meister, Locked nucleic acid-based in situ hybridisation reveals miR-7a as a hypothalamus-enriched microRNA with a distinct expression pattern, J. Neuroendocrinol, vol.24, 2012.

J. W. Hill, C. F. Elias, M. Fukuda, K. W. Williams, E. D. Berglund et al., Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility, Cell Metabolism, vol.11, issue.4, pp.286-297, 2010.
DOI : 10.1016/j.cmet.2010.03.002

D. Huszar, C. A. Lynch, V. Fairchild-huntress, J. H. Dunmore, Q. Fang et al., Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice, Cell, vol.88, issue.1, pp.131-141, 1997.
DOI : 10.1016/S0092-8674(00)81865-6

N. Ibrahim, M. A. Bosch, J. L. Smart, J. Qiu, M. Rubinstein et al., Channels, Endocrinology, vol.144, issue.4, pp.1331-1340, 2002.
DOI : 10.1210/en.2002-221033

Y. S. Lee, The role of leptin-melanocortin system and human weight regulation: lessons from experiments of nature, Ann. Acad. Med. Singapore, vol.38, pp.34-45, 2009.

S. Li, X. Chen, H. Zhang, X. Liang, Y. Xiang et al., Differential expression of microRNAs in mouse liver under aberrant energy metabolic status, The Journal of Lipid Research, vol.50, issue.9, pp.1756-1765, 2009.
DOI : 10.1194/jlr.M800509-JLR200

P. Lovis, E. Roggli, D. R. Laybutt, S. Gattesco, J. Yang et al., Alterations in MicroRNA Expression Contribute to Fatty Acid-Induced Pancreatic ??-Cell Dysfunction, Diabetes, vol.57, issue.10, pp.2728-2736, 2008.
DOI : 10.2337/db07-1252

S. Margetic, C. Gazzola, G. G. Pegg, and R. A. Hill, Leptin: a review of its peripheral actions and interactions, International Journal of Obesity, vol.26, issue.11, pp.1407-1433, 2002.
DOI : 10.1038/sj.ijo.0802142

T. M. Mizuno, S. P. Kleopoulos, H. T. Bergen, J. L. Roberts, C. A. Priest et al., Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin, Diabetes, vol.47, issue.2, pp.294-297, 1998.
DOI : 10.2337/diab.47.2.294

G. J. Morton, D. E. Cummings, D. G. Baskin, G. S. Barsh, and M. W. Schwartz, Central nervous system control of food intake and body weight, Nature, vol.52, issue.7109, pp.289-295, 1038.
DOI : 10.1016/j.physbeh.2004.04.034

L. Mounien, P. Bizet, I. Boutelet, G. Gourcerol, M. Basille et al., Expression of PACAP Receptor mRNAs by Neuropeptide Y Neurons in the Rat Arcuate Nucleus, Annals of the New York Academy of Sciences, vol.1070, issue.1, pp.457-461, 2006.
DOI : 10.1196/annals.1317.061

L. Mounien, P. Bizet, I. Boutelet, G. Gourcerol, A. Fournier et al., Pituitary adenylate cyclase-activating polypeptide directly modulates the activity of proopiomelanocortin neurons in the rat arcuate nucleus, Neuroscience, vol.143, issue.1, pp.155-163, 2006.
DOI : 10.1016/j.neuroscience.2006.07.022

L. Mounien, P. Bizet, I. Boutelet, H. Vaudry, and S. Jégou, Expression of Melanocortin MC3 and MC4 Receptor mRNAs by Neuropeptide Y Neurons in the Rat Arcuate Nucleus, Neuroendocrinology, vol.82, issue.3-4, pp.164-170, 1159.
DOI : 10.1159/000091737

L. Mounien, J. Do-rego, P. Bizet, I. Boutelet, G. Gourcerol et al., Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System, Neuropsychopharmacology, vol.52, issue.2, pp.424-43573, 2008.
DOI : 10.1038/12506
URL : https://hal.archives-ouvertes.fr/inserm-00349463

L. Mounien, N. Marty, D. Tarussio, S. Metref, D. Genoux et al., Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons, The FASEB Journal, vol.24, issue.6, pp.1747-1758, 2010.
DOI : 10.1096/fj.09-144923

N. Nakanishi, Y. Nakagawa, N. Tokushige, N. Aoki, T. Matsuzaka et al., The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice, Biochemical and Biophysical Research Communications, vol.385, issue.4, pp.492-496, 2009.
DOI : 10.1016/j.bbrc.2009.05.058

K. N. Nilaweera, P. Barrett, J. G. Mercer, M. , and P. J. , Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin, Neuroscience, vol.119, issue.3, pp.713-720, 2003.
DOI : 10.1016/S0306-4522(02)00869-2

M. M. Ollmann, B. D. Wilson, Y. K. Yang, J. A. Kerns, Y. Chen et al., Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein, Science, vol.278, issue.5335, pp.135-138, 1997.
DOI : 10.1126/science.278.5335.135

L. E. Parton, C. P. Ye, R. Coppari, P. J. Enriori, B. Choi et al., Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity, Nature, vol.154, issue.7159, pp.228-232, 1038.
DOI : 10.1038/nature06098

S. Pinto, A. G. Roseberry, H. Liu, S. Diano, M. Shanabrough et al., Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin, Science, vol.304, issue.5667, pp.110-115, 2004.
DOI : 10.1126/science.1089459

L. Plum, B. F. Belgardt, and J. C. Brüning, Central insulin action in energy and glucose homeostasis, Journal of Clinical Investigation, vol.116, issue.7, pp.1761-1766, 2006.
DOI : 10.1172/JCI29063

D. Porte, . Jr, D. G. Baskin, and M. W. Schwartz, Leptin and Insulin Action in the Central Nervous System, Nutrition Reviews, vol.60, issue.suppl 10, pp.20-29, 1301.
DOI : 10.1301/002966402320634797

M. N. Poy, J. Hausser, M. Trajkovski, M. Braun, S. Collins et al., miR-375 maintains normal pancreatic ??- and ??-cell mass, Proceedings of the National Academy of Sciences, vol.106, issue.14, pp.5813-5818, 2009.
DOI : 10.1073/pnas.0810550106

S. Sangiao-alvarellos, L. Pena-bello, M. Manfredi-lozano, M. Tena-sempere, C. et al., Perturbation of Hypothalamic MicroRNA Expression Patterns in Male Rats After Metabolic Distress: Impact of Obesity and Conditions of Negative Energy Balance, Endocrinology, vol.155, issue.5, pp.1838-1850, 2014.
DOI : 10.1210/en.2013-1770

M. Schneeberger, J. Altirriba, A. García, Y. Esteban, C. Castaño et al., Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity, Molecular Metabolism, vol.2, issue.2, pp.74-85, 2012.
DOI : 10.1016/j.molmet.2012.10.001

A. I. Smith and J. W. Funder, Proopiomelanocortin Processing in the Pituitary, Central Nervous System, and Peripheral Tissues, Endocrine Reviews, vol.9, issue.1, pp.159-179, 1988.
DOI : 10.1210/edrv-9-1-159

S. G. Tattikota, T. Rathjen, S. J. Mcanulty, H. Wessels, I. Akerman et al., Argonaute2 Mediates Compensatory Expansion of the Pancreatic ?? Cell, Cell Metabolism, vol.19, issue.1, pp.122-134, 2014.
DOI : 10.1016/j.cmet.2013.11.015

R. C. Thompson, M. Deo, T. , and D. L. , Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes, Methods, vol.43, issue.2, 2007.
DOI : 10.1016/j.ymeth.2007.04.008

K. W. Williams, L. O. Margatho, C. E. Lee, M. Choi, S. Lee et al., Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons, Journal of Neuroscience, vol.30, issue.7, pp.2472-2479, 2010.
DOI : 10.1523/JNEUROSCI.3118-09.2010

H. Xie, B. Lim, and H. F. Lodish, MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity, Diabetes, vol.58, issue.5, pp.1050-1057, 2009.
DOI : 10.2337/db08-1299

L. Yaswen, N. Diehl, M. B. Brennan, and U. Hochgeschwender, Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin, Nat. Med, vol.5, pp.1066-1070, 1999.

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