Lanthanide Luminescence Modulation by Cation–π Interaction in a Bioinspired Scaffold: Selective Detection of Copper(I)

Manon Isaac (1) , Sergey A. Denisov (2) , Amandine Roux (1) , Daniel Imbert (3) , Gediminas Jonusauskas (4) , Nathan Mc Clenaghan (2) , Olivier Sénèque (1)

1 LCBM - UMR 5249 - Laboratoire de Chimie et Biologie des Métaux
2 ISM - Institut des Sciences Moléculaires
3 RICC - Reconnaissance Ionique et Chimie de Coordination
4 LOMA - Laboratoire Ondes et Matière d'Aquitaine

A prototype luminescent turn-on probe for Cu+ (and Ag+) is described, harnessing a selective binding site (log Kass=9.4 and 7.3 for Cu+ and Ag+, respectively) based on the coordinating environment of the bacterial metallo-chaperone CusF, integrated with a terbium-ion-signaling moiety. Cation–π interactions were shown to enhance tryptophan triplet population, which subsequently sensitized, on the microsecond timescale, the long-lived terbium emission, offering a novel approach in bioinspired chemosensor design.

Mots clés: cation-pi interactions; peptides; copper; luminescence; terbium

Domaines: Chimie; Matériaux; Biotechnologies

Manon Isaac, Sergey A. Denisov, Amandine Roux, Daniel Imbert, Gediminas Jonusauskas, et al.. Lanthanide Luminescence Modulation by Cation–π Interaction in a Bioinspired Scaffold: Selective Detection of Copper(I). Angewandte Chemie International Edition, 2015, 54 (39), pp.11453-11456. ⟨10.1002/anie.201505733⟩. ⟨hal-01211550⟩