Oxidative inactivation of NiFeSe hydrogenase

Pierre Ceccaldi (1) , Marta Marques (2) , Vincent Fourmond (1) , Inês Cardoso Pereira (2) , Christophe Léger (1)

1 BIP - Bioénergétique et Ingénierie des Protéines
2 ITQB - Instituto de Tecnologia Química e Biológica António Xavier

We propose a resolution to the paradox that spectroscopic studies of NiFeSe hydrogenase have not revealed any major signal attributable to NiIII states formed upon reaction with O2, despite the fact that two inactive states are formed upon either aerobic or anaerobic oxidation.

Mots clés: electrochemistry; hydrogenase

Domaines: Chimie; Biochimie, Biologie Moléculaire

Pierre Ceccaldi, Marta Marques, Vincent Fourmond, Inês Cardoso Pereira, Christophe Léger. Oxidative inactivation of NiFeSe hydrogenase. Chemical Communications, 2015, ⟨10.1039/C5CC05930E⟩. ⟨hal-01211493⟩