Probiotics, prebiotics, and the host microbiome: the science of translation

Bryon Petschow (1) , Joel Dore (2) , Patricia Hibberd (3) , Timothy Dinan (4) , Gregor Reid (5, 6) , Martin Blaser (7) , Patrice D. Cani (8) , Fred H. Degnan (9) , Jane Foster (10) , Glenn Gibson (11) , John Hutton (12) , Todd R. Klaenhammer (13) , Ruth Ley (14) , Max Nieuwdorp (15) , Bruno Pot (16) , David Relman (17) , Andrew Serazin (18) , Mary Ellen Sanders (19)

1 Transcend Biomedical Communications LLC
2 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
3 HMS - Harvard Medical School [Boston]
4 UCC - University College Cork
5 UWO - University of Western Ontario
6 Lawson Health Research Institute
7 School of Medicine
8 Louvain Drug Research Institute, WELBIO (Walloon Excellence in Life sciences and BIOtechnology)
9 King and Spalding LLP
10 McMaster University [Hamilton, Ontario]
11 UOR - University of Reading
12 University of York [York, UK]
13 NC State - North Carolina State University [Raleigh]
14 Cornell University [New York]
15 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
16 Institut Pasteur de Lille
17 School of Medicine
18 Matatu LLC
19 Dairy and Food Culture Technologies

Recent advances in our understanding of the community structure and function of the human microbiome have implications for the potential role of probiotics and prebiotics in promoting human health. A group of experts recently met to review the latest advances in microbiota/microbiome research and discuss the implications for development of probiotics and prebiotics, primarily as they relate to effects mediated via the intestine. The goals of the meeting were to share recent advances in research on the microbiota, microbiome, probiotics, and prebiotics, and to discuss these findings in the contexts of regulatory barriers, evolving healthcare environments, and potential effects on a variety of health topics, including the development of obesity and diabetes; the long-term consequences of exposure to antibiotics early in life to the gastrointestinal (GI) microbiota; lactose intolerance; and the relationship between the GI microbiota and the central nervous system, with implications for depression, cognition, satiety, and mental health for people living in developed and developing countries. This report provides an overview of these discussions.

Mots clés: microbiome; probiotics; prebiotics; intestinal microbiota; health disorders

Domaines: Sciences du Vivant [q-bio]

Bryon Petschow, Joel Dore, Patricia Hibberd, Timothy Dinan, Gregor Reid, et al.. Probiotics, prebiotics, and the host microbiome: the science of translation. Annals of the New York Academy of Sciences, 2013, 1306, pp.1-17. ⟨10.1111/nyas.12303⟩. ⟨hal-01204446⟩