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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.

Abstract : We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.
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https://hal.archives-ouvertes.fr/hal-01201573
Contributor : Pierre Neuvial <>
Submitted on : Thursday, September 17, 2015 - 3:33:32 PM
Last modification on : Tuesday, November 3, 2020 - 1:02:05 PM

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Houtan Noushmehr, Daniel J Weisenberger, Kristin Diefes, Heidi S Phillips, Kanan Pujara, et al.. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.. Cancer Cell, Elsevier, 2010, 17 (5), pp.510-22. ⟨hal-01201573⟩

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