Subtype and pathway specific responses to anticancer compounds in breast cancer. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2012

Subtype and pathway specific responses to anticancer compounds in breast cancer.

Nicholas J Wang
  • Fonction : Auteur
Elizabeth Purdom
Kenneth W Wood
  • Fonction : Auteur
Peter G Smith
  • Fonction : Auteur
Joel Greshock
  • Fonction : Auteur
Kurtis E Bachman
  • Fonction : Auteur

Résumé

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.

Dates et versions

hal-01201568 , version 1 (17-09-2015)

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Citer

Laura M Heiser, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C Benz, Theodore C Goldstein, et al.. Subtype and pathway specific responses to anticancer compounds in breast cancer.. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (8), pp.2724-9. ⟨hal-01201568⟩
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