Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions

Philippe Guyant (1) , Vincent Corbel (2, 3) , Philippe J Guérin (4, 5) , Adeline Lautissier (6) , François Nosten (4, 7) , Sébastien Boyer (8) , Marc Coosemans (9, 10) , Arjen M Dondorp (4, 11) , Véronique Sinou (12) , Shunmay Yeung (13) , Nicholas White (4, 14)

1 Partners for Development [Phnom Penh, Cambodia]
2 KU - Kasetsart University [Bangkok, Thailand]
3 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
4 Centre for Tropical Medicine and Global Health [Oxford, UK]
5 WWARN - WorldWide Antimalarial Resistance Network
6 Initiative 5%
7 SMRU - Shoklo Malaria Research Unit [Mae Sot, Thailand]
8 Institut Pasteur de Madagascar
9 UA - University of Antwerp
10 ITM - Institute of Tropical Medicine [Antwerp]
11 Mahidol University [Bangkok]
12 IP-TPT - Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques
13 LSHTM - London School of Hygiene and Tropical Medicine
14 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes

This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission. The role of operational research and the interactions between research institutions, National Malaria Control Programmes, Civil Society Organizations, and of financial and technical partners to address those challenges and to accelerate translation of research into policies and programmes were debated. The threat and the emergency of the artemisinin resistance spread and independent emergence in the GMS was intensely debated as it is now close to the border of India. The need for key messages, based on scientific evidence and information available and disseminated without delay, was highlighted as crucial for an effective and urgent response.

Mots clés: PLASMODIUM-FALCIPARUM MALARIA; DIHYDROARTEMISININ-PIPERAQUINE FAILURE; ARTEMETHER-LUMEFANTRINE; ARTEMISININ RESISTANCE; CHLOROQUINE RESISTANCE; KNOCKDOWN RESISTANCE; ANOPHELES-GAMBIAE; SOUTHEAST-ASIA; MEKONG REGION; CAMBODIA

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Philippe Guyant, Vincent Corbel, Philippe J Guérin, Adeline Lautissier, François Nosten, et al.. Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions. Malaria Journal, 2015, 14, pp.279. ⟨10.1186/s12936-015-0802-4⟩. ⟨hal-01199794⟩