In vitro detection method of biomarker using luminescent MOFs
Résumé
The global economic impact of the five leading non-communicable diseases (NCDs) â cardiovascular disease (CVD), chronic respiratory disease, cancer, diabetes and mental ill-health â could total US$ 47 trillion by 2030, according to a study released by the World Economic Forum in 2011. According to the World health organization, the four major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases and diabetes) are responsible for 82% of NCDs deaths which corresponds to 31 million deaths in 2012. All these diseases involve a variation of H2S concentration in blood. Indeed, H2S is the 3rd endogenously generated gaseous signaling compound and itâs involved in the biological systems under physiological and pathological conditions.[1] What about the development of accurate point-of-care testing for H2S blood concentration using fluorescent MOF as sensor? Early diagnostic will allow avoiding millions of deaths every year.
We developed a functionalized MOF, via post-synthetic modification, able to specifically respond by a fluorescence turn-on mechanism to physiological (ie healthy person) and pathological (ie sick person) H2S concentration. The presentation will address the synthesis and characterization of MOF bearing functional moieties. Results of the specific reaction leading to an increase of MOF fluorescence when triggered by various H2S concentration will be also presented.
[1] M. Whiteman et al., Clinical Science (2011) 121, 459-488 / R. Wang, Physiol Rev (2012) 98, 791-896