Connectivity-Based Parcellation: Critique and Implications

Abstract : Regional specialization and functional integration are often viewed as two fundamental principles of human brain organization. They are closely intertwined because each functionally specialized brain region is probably characterized by a distinct set of long-range connections. This notion has prompted the quickly developing family of connectivity-based parcellation (CBP) methods in neuroi-maging research. CBP assumes that there is a latent structure of parcels in a region of interest (ROI). First, connectivity strengths are computed to other parts of the brain for each voxel/vertex within the ROI. These features are then used to identify functionally distinct groups of ROI voxels/vertices. CBP enjoys increasing popularity for the in-vivo mapping of regional specialization in the human brain. Due to the requirements of different applications and datasets, CBP has diverged into a heterogeneous family of methods. This broad overview critically discusses the current state as well as the commonal-ities and idiosyncrasies of the main CBP methods. We target frequent concerns faced by novices and veterans to provide a reference for the investigation and review of CBP studies.
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Contributeur : Danilo Bzdok <>
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Simon Eickhoff, Bertrand Thirion, Gaël Varoquaux, Danilo Bzdok. Connectivity-Based Parcellation: Critique and Implications. Human Brain Mapping, Wiley, 2016, pp.22. 〈10.1002/hbm.22933〉. 〈hal-01184563〉



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