Skip to Main content Skip to Navigation
Journal articles

Genome expansion of Arabis alpina linked with retrotransposition and reduced symmetric DNA methylation

Abstract : Despite evolutionary conserved mechanisms to silence transposable element activity, there are drastic differences in the abundance of transposable elements even among closely related plant species. We conducted a de novo assembly for the 375 Mb genome of the perennial model plant, Arabis alpina. Analysing this genome revealed long-lasting and recent transposable element activity predominately driven by Gypsy long terminal repeat retrotransposons, which extended the lowrecombining pericentromeres and transformed large formerly euchromatic regions into repeat-rich pericentromeric regions. This reduced capacity for long terminal repeat retrotransposon silencing and removal in A. alpina co-occurs with unexpectedly low levels of DNA methylation. Most remarkably, the striking reduction of symmetrical CG and CHG methylation suggests weakened DNA methylation maintenance in A. alpina compared with Arabidopsis thaliana. Phylogenetic analyses indicate a highly dynamic evolution of some components of methylation maintenance machinery that might be related to the unique methylation in A. alpina.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-01179557
Contributor : Archive Ouverte Prodinra Connect in order to contact the contributor
Submitted on : Wednesday, July 22, 2015 - 8:10:46 PM
Last modification on : Wednesday, November 17, 2021 - 12:31:42 PM

Links full text

Identifiers

Collections

Citation

Eva-Maria Willing, Vimal Rawat, Terezie Mandáková, Florian Maumus, Geo Velikkakam James, et al.. Genome expansion of Arabis alpina linked with retrotransposition and reduced symmetric DNA methylation. Nature Plants, Nature Publishing Group, 2015, 1 (2), pp.14023-14028. ⟨10.1038/nplants.2014.23⟩. ⟨hal-01179557⟩

Share

Metrics

Record views

1644