Cyclodextrin Polyrotaxanes as a Highly Modular Platform for the Development of Imaging Agents

Jean Wilfried Fredy (1) , Jérémy Scelle (1) , Aurélie Guenet (1) , Elodie Morel (1) , Ségolène Adam de beaumais (1) , Mickaël Ménand (1) , Valérie Marvaud (1) , Célia S. Bonnet (2) , Éva Tóth (2) , Matthieu Sollogoub (1) , Guillaume Vives (1) , Bernold Hasenknopf (1)

1 IPCM - Institut Parisien de Chimie Moléculaire
2 CBM - Centre de biophysique moléculaire

Selectively functionalized cyclodextrins with a bodipy fluorescent tag or Gd3+ complex were synthetized and threaded onto a polyammonium chain to form polyrotaxanes. This modular supramolecular assembly makes an ideal platform for bimodal (fluorescent and MRI) imaging applications.

Mots clés: bimodal imaging; cyclodextrin; polyrotaxane

Domaines: Sciences du Vivant [q-bio]

Jean Wilfried Fredy, Jérémy Scelle, Aurélie Guenet, Elodie Morel, Ségolène Adam de beaumais, et al.. Cyclodextrin Polyrotaxanes as a Highly Modular Platform for the Development of Imaging Agents. Chemistry - A European Journal, 2014, 20 (35), pp.10915-10920. ⟨10.1002/chem.201403635⟩. ⟨hal-01178990⟩