Influence of the synthetic method on the properties of two-photon-sensitive mesoporous organosilica nanoparticles

Jonas G. Croissant (1) , Olivier Mongin (2) , Vincent Hugues (3) , Mireille Blanchard-Desce (3) , Xavier Cattoën (4) , Michel Wong Chi Man (1) , Vanja Stojanovic (5) , Clarence Charnay (1) , Marie Maynadier (6, 5) , Magali Gary-Bobo (5) , Marcel Garcia (5) , Laurence Raehm (1) , Jean-Olivier Durand (1)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 ISCR - Institut des Sciences Chimiques de Rennes
3 ISM - Institut des Sciences Moléculaires
4 NEEL - OPTIMA - Optique et Matériaux
5 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
6 NMS - NanoMedSyn

Herein we report the modulation of the properties of mesoporous silica nanoparticles (NPs) via various synthetic approaches. Three types of elaborations were compared, one in aqueous media at 25 °C, and the other two at 80 °C in water or in a water–ethanol mixture. For all these methods, an alkoxysilylated two-photon photosensitizer (2PS) was co-condensed with tetraethylorthosilicate (TEOS) in the presence of cetyltrimethylammonium bromide (CTAB), leading to five two-photon-sensitive mesoporous silica (M2PS) NPs. The M2PS NP porous structure could be tuned from radial to worm-like and MCM-41 types of organization. Besides, the 2PS precursor spatial dispersion was found to be highly dependent on both the 2PS initial concentration and the elaboration process. As a result, two-photon properties were modulated by the choice of the synthesis, the best results being found in aqueous media at 25 or 80 °C. Finally, the M2PS NPs were used for in vitro two-photon imaging of cancer cells.

Mots clés: Mesoporous silica nanoparticles; two-photon; cancer cells; imaging; cross-section

Domaines: Chimie organique

Jonas G. Croissant, Olivier Mongin, Vincent Hugues, Mireille Blanchard-Desce, Xavier Cattoën, et al.. Influence of the synthetic method on the properties of two-photon-sensitive mesoporous organosilica nanoparticles. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2015, 3 (26), pp.5182--5188. ⟨10.1039/c5tb00787a⟩. ⟨hal-01175463⟩