Isolated Neutral Peptides

Eric Gloaguen (1, 2, 3) , M. Mons (2, 3, 1)

1 SBM - Structures BioMoléculaires
2 LFP - URA 2453 - Laboratoire Francis PERRIN
3 LIDYL - Laboratoire Interactions, Dynamiques et Lasers (ex SPAM)

This chapter examines the structural characterisation of isolated neutral amino-acids and peptides. After a presentation of the experimental and theoretical state-of-the-art in the field, a review of the major structures and shaping interactions is presented. Special focus is made on conformationally-resolved studies which enable one to go beyond simple structural characterisation; probing flexibility and excited-state photophysics are given as examples of promising future directions.

Mots clés: Amide • Amino-acid • Backbone-side chain interactions • Conforma- tion-selective IR spectroscopy • Gas phase laser spectroscopy • Hydrates • Second- ary structures • Supersonic expansion

Domaines: Chimie théorique et/ou physique

Eric Gloaguen, M. Mons. Isolated Neutral Peptides. Topics in Current Chemistry, 364, pp.225-270, 2015, Gas-phase IR Spectroscopy for the Structural Characterization of Biomolecules, ⟨10.1007/128_2014_580⟩. ⟨hal-01170925⟩