Straightforward selective synthesis of linear 1-O-alkyl glycerol and di-glycerol monoethers.

Yan Shi (1) , Wissam Dayoub (2) , Alain Favre-Réguillon (2) , Guo-Rong Chen (1) , Marc Lemaire (2)

1 Institute of Materials Science and Engineering, East China University of Science and Technology
2 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

1-O-Alkyl glycerol and di-glycerol monoethers are, respectively, obtained in high yields and selectivity by catalytic reductive etherification of mono- and di-glycerol with linear aldehydes in the presence of 0.5 mol % of Pd/C under 10 bars of hydrogen using a Brønsted acid as co-catalyst.

Mots clés: 1-O-Alkyl mono-; di-glycerol monoethers; Reductive alkylation; Glycerol; Di-glycerol

Domaines: Chimie organique

Yan Shi, Wissam Dayoub, Alain Favre-Réguillon, Guo-Rong Chen, Marc Lemaire. Straightforward selective synthesis of linear 1-O-alkyl glycerol and di-glycerol monoethers.. Tetrahedron Letters, 2009, 50 (49), pp.6891-6893. ⟨10.1016/j.tetlet.2009.09.134⟩. ⟨hal-01166168⟩