Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria

Abstract : Background: Plasmodium falciparum is transmitted from humans to Anopheles mosquito vectors via the sexual erythrocytic forms termed gametocytes. Erythrocyte filtration through microsphere layers (microsphiltration) had shown that circulating gametocytes were deformable. Compounds reducing gametocyte deformability would induce their splenic clearance, thus remove them from the blood circulation and block malaria transmission.
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Julien Duez, John P. Holleran, Papa Alioune Ndour, Sasdekumar Loganathan, Pascal Amireault, et al.. Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, pp.AAC.05030-14. ⟨10.1128/AAC.05030-14⟩. ⟨hal-01158996⟩

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