Frequency and location of dilated Virchow-Robin spaces in elderly people: a population-based 3D MR imaging study.

Y-C Zhu (1, 2) , Carole Dufouil (1) , Bernard Mazoyer (3) , A Soumaré (1) , F Ricolfi (4) , Christophe Tzourio (1) , H Chabriat (1)

1 INSERM Unit 708-Neuroepidemiology, Paris, France
2 Department of Neurology, Peking Union Medical College Hospital, Beijing, China
3 GIN - UMR 5296 - Groupe d'Imagerie Neurofonctionnelle
4 Service de neuroradiologie, imagerie des urgences [CHU de Dijon]

dVRS have been previously associated with aging and cerebrovascular diseases. However, little is known about their prevalence and topographic distribution in the general elderly population. dVRS were evaluated by using high-resolution 3D MR imaging in 1826 subjects enrolled in the 3C-Dijon MR imaging study. On T1-weighted MR imaging, dVRS were detected according to 3D imaging criteria and rated by using 4-level severity scores based in the BG or in the WM. The number and anatomic location of large dVRS (≥3 mm) were recorded. dVRS were observed in the BG or WM in every subject. The severity of dVRS was significantly associated with higher age in both the BG and WM, whereas sex was related to the severity of dVRS only in the BG. Large dVRS were detected in 33.2% of participants. Status cribrosum was found in 1.3% of participants. dVRS were also highly prevalent within the hippocampus (44.5%) and hypothalamus (11.6%). dVRS are always detected in the BG or WM in elderly people, and large dVRS are also prevalent. The topographic distribution of dVRS is not uniform within the brain and may depend on anatomic or pathologic characteristics interacting with aging and sex.

Domaines: Neurosciences

Y-C Zhu, Carole Dufouil, Bernard Mazoyer, A Soumaré, F Ricolfi, et al.. Frequency and location of dilated Virchow-Robin spaces in elderly people: a population-based 3D MR imaging study.. American Journal of Neuroradiology, 2011, 32 (4), pp.709-13. ⟨hal-01157621⟩