Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?

Giselle Charron 1 Evelyne Doudnikoff 1 Marie-Helene Canron 1 Qin Li Céline Véga 1 Sebastien Marais Jérôme Baufreton 1 Anne Vital 1 Stéphane H R Oliet 2 Erwan Bezard 1
1 IMN - Institut des Maladies Neurodégénératives [Bordeaux]
2 Physiopathologie du système nerveux central - Institut François Magendie
Abstract : The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson's disease (PD) remains to be elucidated. Before embarking into physiological investigations of the yet-to-be-identified "tripartite" synapses in the basal ganglia in general and the striatum in particular, we therefore characterized anatomically the PD-related modifications in astrocytic morphology, the changes in astrocytic network connections and the consequences on the spatial relationship between astrocytic processes and asymmetric synapses in normal and PD-like conditions in experimental and human PD. Our results unravel a dramatic regulation of striatal astrocytosis supporting the hypothesis of a key role in (dys) regulating corticostriatal transmission. Astrocytes and their various properties might thus represent a therapeutic target in PD.
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https://hal.archives-ouvertes.fr/hal-01155082
Contributeur : Jérôme Baufreton <>
Soumis le : mardi 26 mai 2015 - 10:11:39
Dernière modification le : mardi 5 novembre 2019 - 10:00:06

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Giselle Charron, Evelyne Doudnikoff, Marie-Helene Canron, Qin Li, Céline Véga, et al.. Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?. Frontiers in Aging Neuroscience, Frontiers, 2013, 6, pp.258. ⟨10.3389/fnagi.2014.00258⟩. ⟨hal-01155082⟩

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