Potential of plasma based soft and/or combined cancer treatments

Abstract : The antitumor effect of Non Thermal Plasmas (NTP) has been clearly shown in vivo on murine models with various cancer types (bladder, colon, glioblastoma, melanoma, ovary, pancreas). Although the mechanism is far from being fully understood, the therapeutic effect is now totally admitted. To date, the literature reports mainly induction of apoptosis, effect which is not restricted to cancer cells and probably mask other aspects of the NTP for cancer therapy. In case of plasma jet experiments, the observed effect are most of the time attributed to the very rich chemistry generated by the interaction of the rare gas plasma plume with the surrounding environment constituted either from the ambient air, or this last one in complex interaction with liquids at the interface with the targeted organ. Our recent experiments performed on tissue oxygenation1 or breast cancer treatments on immunocompetent mice2 lead to the conclusion that probably the involved chemistry couldn’t, alone, completely allow to describe the observed phenomena. This, especially under very soft treatment conditions, is suggesting possible triggering of some immune system chain processes, but also possible modifications in the microenvironment of tissue and tumors. In this context, there is still an unknown role of the electric field associated with the ionization front or generated in the environment of the plasma plume tip. Taking into consideration the recent vessel normalization based-cancer treatment, the NTP effect should be further investigated in view of blood vessels structure and function (blood flow) as well as tumor hypoxia compensation to confirm a possible NTP-based adjuvant approach for cancer treatments. These results suggest new ways, especially combined therapy, to consider the plasma and its therapeutic delivery in NTP-based tumor therapy. All these aspects will be discussed during the presentation, including recent results on electric field measurements in plasma biological application conditions. This work is supported by the APR Region Centre PLASMEDNORM. References [1] G. Collet, E. Robert, A. Lenoir, M. Vandamme, T. Darny, S. Dozias, C. Kieda, , J.M. Pouvesle, “Plasma jet-induced tissue oxygenation: potentialities for new therapeutic strategies” Plasma Sources Sci. Technol. 23 (2014) 012005 [2] G. Collet, L. Ridou, E. Robert, M. Vandamme, T. Darny, S. Dozias, C. Kieda, , J.M. Pouvesle “NTP antitumor soft treatment: evidence of a triggering effect? ”, ICPM5, May 18-23, 2014, Nara (Japan)
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https://hal.archives-ouvertes.fr/hal-01148938
Contributor : Jean-Michel Pouvesle <>
Submitted on : Tuesday, May 5, 2015 - 5:06:34 PM
Last modification on : Friday, April 26, 2019 - 9:06:02 AM

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Jean-Michel Pouvesle, Guillaume Collet, Eric Robert, Loick Ridou, Sebatien Dozias, et al.. Potential of plasma based soft and/or combined cancer treatments. IWPCT 2, M. Hori, Nogoya University, Mar 2015, Nagoya, Japan. ⟨hal-01148938⟩

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