PEDOT-modified integrated microelectrodes for the detection of ascorbic acid, dopamine and uric acid

Fadhila Sekli-Belaidi (1, 2) , Aurélie Civélas (1) , Valentina Castagnola (3) , Aliki Tsopela (1) , Laurent Mazenq (4) , Pierre Gros (2) , Jérôme Launay (1) , Pierre Temple-Boyer (1)

1 LAAS-MICA - Équipe MICrosystèmes d'Analyse
2 LGC - Laboratoire de Génie Chimique
3 LAAS-NBS - Équipe NanoBioSystèmes
4 LAAS-TEAM - Service Techniques et Équipements Appliqués à la Microélectronique

Integrated (Pt/PEDOT–Pt–Ag/AgCl) and (Au/PEDOT–Pt–Ag/AgCl) electrochemical microcells (ElecCell) were elaborated for the detection of ascorbic acid, dopamine and uric acid by differential pulse voltammetry. Specific attention was brought to the integration of poly(3,4-ethylenedioxythiophene) (PEDOT) film by electropolymerization. Gold and platinum working microelectrodes were investigated while using ethylenedioxythiophene (EDOT) electrodeposition processes in water or acetonitrile solvents. For the three antioxidant species, best (multi-)detection properties were obtained for acetonitrile-based PEDOT films deposited on gold working electrode. Thus, using integrated (Au/PEDOT–Pt–Ag/AgCl) Elec-Cell microdevices, analytical performances were determined for ascorbic acid, dopamine and uric acid, exhibiting high selectivity (oxidation potential: −40, 150 and 280 mV, respectively), linear concentration range from 0.1 to 300 µM, high sensitivities (0.85, 1.65 and 3.06 µA/ µM cm2, respectively) and low detection limit (0.2 µM, 0.1 µM and 0.05 µM, respectively).

Mots clés: Integrated microelectrode; Electrochemical microcell; PEDOT; Ascorbic acid; Dopamine; Uric acid; Integrated microelectrode

Domaines: Génie chimique; Génie des procédés

Fadhila Sekli-Belaidi, Aurélie Civélas, Valentina Castagnola, Aliki Tsopela, Laurent Mazenq, et al.. PEDOT-modified integrated microelectrodes for the detection of ascorbic acid, dopamine and uric acid. Sensors and Actuators B: Chemical, 2015, 214, pp. 1-9. ⟨10.1016/j.snb.2015.03.005⟩. ⟨hal-01148710⟩