The first 2 IB ,3 IA -heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes

S. Letort (1) , D. Mathiron (2) , T. Grel (1) , C. Albaret (3) , S. Daulon (3) , F. Djedaïni-Pilard (4) , G. Gouhier (1) , F. Estour (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 PFA - Plateforme Analytique - UPJV
3 MNRBC - Maîtrise nucléaire, radiologique, bactériologique et chimique
4 LG2A - Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378

Novel 2,3-heterodisubstituted β-cyclodextrin derivatives were designed as artificial enzymes to degrade chemical warfare agents. One of them reduced the acetylcholinesterase inhibitory potential by soman faster than its monosubstituted analog.

Domaines: Chimie

S. Letort, D. Mathiron, T. Grel, C. Albaret, S. Daulon, et al.. The first 2 IB ,3 IA -heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes. Chemical Communications, 2015, 51 (13), pp.2601-2604. ⟨10.1039/c4cc09189b⟩. ⟨hal-02947796⟩