An Electroneutral Macrocyclic Iron(II) Complex That Enhances MRI Contrast in Vivo

Fayçal Touti (1) , Akhilesh Kumar Singh (1) , Philippe Maurin (1) , Laurence Canaple (2) , Olivier Beuf (3) , Jacques Samarut (2) , Jens Hasserodt (1)

1 LC - Laboratoire de Chimie - UMR5182
2 IGFL - Institut de Génomique Fonctionnelle de Lyon
3 RMN et optique : De la mesure au biomarqueur

The first example of a macrocyclic ferrous complex, where two tetrazolyl pendent arms compensate the charge of the metal center, is synthesized and examined for its capacity to enhance MRI contrast in vitro and in vivo in the mouse.

Mots clés: PENDANT-ARM; AGENTS; 1,4,7-TRIAZACYCLONONANE; LIGANDS; DESIGN; EQUILIBRIA; BASE; SPIN

Mots clés: METAL-COMPLEXES; PROBES

Domaines: Chimie; Chimie de coordination; Chimie thérapeutique

Fayçal Touti, Akhilesh Kumar Singh, Philippe Maurin, Laurence Canaple, Olivier Beuf, et al.. An Electroneutral Macrocyclic Iron(II) Complex That Enhances MRI Contrast in Vivo. Journal of Medicinal Chemistry, 2011, 54 (12), pp.4274-4278. ⟨10.1021/jm2002298⟩. ⟨hal-01121312⟩