Fluoxetine accumulation and metabolism as exposure biomarker to better understand biological effects in gastropods

Accumulation et metabolisation de la fluoxétine. Biomarqueur d'exposition pour la compréhension des effets biologiques chez des gastéropodes

M. Gust (1) , C. Cren Olivé (2) , A. Bulete (2) , T. Buronfosse (3) , J. Garric (1)

1 UR MALY - Milieux aquatiques, écologie et pollutions
2 SCA - Service Central d'Analyse
3 VAS - VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement

Fluoxetine is a widely used antidepressant frequently found in wastewater treatment plant effluent and in aquatic ecosystems at concentrations below μg/L. Numerous studies have explored the sensitivity of invertebrates to waterborne fluoxetine showing marked differences of sensitivity. In a previous study, the New-Zealand mudsnail, Potamopyrgus antipodarum, and the European valve snail, Valvata piscinalis, were exposed to waterborne fluoxetine (3.7-100 μg/L) during 42 days. While effects were observed on the mudsnail reproduction and F1, the valve snail was not affected. Several assumptions were proposed to explain these results including dissimilar metabolic capacities or bioavailability of fluoxetine for the snails. The aim of this study was to asses if differential sensitivity of gastropods snails to fluoxetine could be explained by its bioaccumulation and metabolism into norfluoxetine.

Mots clés: GASTEROSTEIDAE; FLUOXETINE; TOXICITE; BIOMARQUEUR

Domaines: Sciences de l'environnement

M. Gust, C. Cren Olivé, A. Bulete, T. Buronfosse, J. Garric. Fluoxetine accumulation and metabolism as exposure biomarker to better understand biological effects in gastropods. Journal of Xenobiotics, 2013, 3 (1S), pp.8-10. ⟨hal-01117940⟩