Molecular and immunological biomarkers to predict IVIg response

Caroline Galeotti (1, 2) , Srini V Kaveri (3, 1) , Jagadeesh Bayry (1, 3)

1 CRC - Centre de Recherche des Cordeliers
2 Department of pediatric rheumatology
3 International Associated Laboratory IMPACT

Some patients with autoimmune and inflammatory diseases treated with intravenous immunoglobulin G (IVIg) as a first line therapy are refractory. Identification of predictive biomarker(s) to segregate responders and non-responders to IVIg therapy remains critical. A number of biomarkers, particularly in Kawasaki disease, have shown potential for predicting response to IVIg.

Mots clés: Kawasaki disease; Guillain-Barré syndrome; cytokines; Fcγ receptor; intravenous immunoglobulin; immune thrombocytopenia

Domaines: Médecine humaine et pathologie

Caroline Galeotti, Srini V Kaveri, Jagadeesh Bayry. Molecular and immunological biomarkers to predict IVIg response. Trends in Molecular Medicine, 2015, 21 (3), pp.145-147. ⟨10.1016/j.molmed.2015.01.005⟩. ⟨hal-01117084⟩