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Small rigid platforms functionalization with quaternary ammonium: Targeting extracellular matrix of chondrosarcoma

Abstract : This work takes place in the “cartilage targeting strategy”, consisting in using the quaternary ammonium (QA) function as a vector to proteoglycans (PGs) of extracellular matrix (ECM). The objective was to demonstrate that QA could address gadolinium based small rigid platforms (SRP) to PG-rich tumors. SRP were functionalized with QA, radiolabeled with 111Indium and evaluated for biodistribution in vivo, respectively to non functionalized SRP, in two experimental models: (i) the HEMCSS human xenograft model; (ii) the Swarm rat chondrosarcoma (SRC) orthotopic model. The contribution of cellular uptake to tumoral accumulation of nano-objects was also determined from in vitro binding. In the SRC model expressing a highly and homogeneously distributed PG content, tumor accumulation and retention of SRP@QA were increased by 40% as compared to non-functionalized SRP. When considering the radiosensitizing potential of gadolinium based SRP, these results provide hopes for the radiobiological approach of highly resistant tumor such as chondrosarcoma.
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https://hal.archives-ouvertes.fr/hal-01115673
Contributor : Béatrice Rayet <>
Submitted on : Wednesday, February 11, 2015 - 3:02:31 PM
Last modification on : Thursday, April 2, 2020 - 10:48:04 AM

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Elisabeth Miot-Noirault, Aurélien Vidal, Jessica Morlieras, Pauline Bonazza, Philippe Auzeloux, et al.. Small rigid platforms functionalization with quaternary ammonium: Targeting extracellular matrix of chondrosarcoma. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2014, 10 (8), pp.1887-1895. ⟨10.1016/j.nano.2014.06.011⟩. ⟨hal-01115673⟩

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