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Gadolinium-based nanoparticles to improve the hadrontherapy performances

Abstract : Nanomedicine is proposed as a novel strategy to improve the performance of radiotherapy. High-Z nanoparticles are known to enhance the effects of ionizing radiation. Recently, multimodal nanoparticles such as gadolinium-based nanoagents were proposed to amplify the effects of x-rays and g-rays and to improve MRI diagnosis. For tumors sited in sensitive tissues, childhood cases and radioresistant cancers, hadrontherapy is considered superior to x-rays and g-rays. Hadrontherapy, based on fast ion radiation, has the advantage of avoiding damage to the tissues behind the tumor; however, the damage caused in front of the tumor is its major limitation. Here, we demonstrate that multimodal gadolinium-based nanoparticles amplify cell death with fast ions used as radiation. Molecular scale experiments give insights into the mechanisms underlying the amplification of radiation effects. This proof-of-concept opens up novel perspectives for multimodal nanomedicine in hadrontherapy, ultimately reducing negative radiation effects in healthy tissues in front of the tumor.
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Contributor : Béatrice Rayet Connect in order to contact the contributor
Submitted on : Wednesday, February 11, 2015 - 2:13:55 PM
Last modification on : Friday, October 7, 2022 - 3:43:31 AM



Erika Porcel, Olivier Tillement, François Lux, Pierre Mowat, Noriko Usami, et al.. Gadolinium-based nanoparticles to improve the hadrontherapy performances. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10 (8), pp.1601-1608. ⟨10.1016/j.nano.2014.05.005⟩. ⟨hal-01115636⟩



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