Viremia Copy-Years as a Predictive Marker of All-Cause Mortality in HIV-1-Infected Patients Initiating a Protease Inhibitor-Containing Antiretroviral Treatment. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Acquired Immune Deficiency Syndromes - JAIDS Année : 2015

Viremia Copy-Years as a Predictive Marker of All-Cause Mortality in HIV-1-Infected Patients Initiating a Protease Inhibitor-Containing Antiretroviral Treatment.

Résumé

Viremia copy-years (VCY) has been reported as a short-term predictor of mortality. We evaluated the association of this parameter with 10-year outcome within the APROCO-COPILOTE cohort. Prospective data from 1281 HIV-1-infected patients who started a first protease inhibitor-containing regimen in 1997-1999 were analyzed. Patients with baseline plasma viral load (pVL) > 500 copies per milliliter and at least 2 pVL measures from the eighth month of follow-up were selected. VCY was calculated individually over the follow-up as the area under the pVL curve. Multivariate Cox models analyzed the relation between all-cause mortality and the following variables: age, sex, geographical origin, transmission group, HIV infection duration, ART-naive, pVL at baseline, time-dependent CD4 count, and VCY. Nine hundred seventy-nine patients were followed up for a median of 10 years (interquartile range: 5-11.5). At baseline, median (interquartile range) values for duration of HIV infection, pVL, and CD4 cell count were 43 (4-95) months, 4.6 (3.9-5.2) log10 copies per milliliter, and 278 (125-416) cells per cubic millimeter, respectively. At censoring date, 77 patients (8%) had died. VCY >1.4 log10 copies × yrs/mL was an independent predictor of death (hazard ratio: 2.0; 95% confidence interval: 1.2 to 3.5), which was no longer the case after adjustment for the latest pVL value [risk ratio (RR): 1.2 for 1 additional log10 copies per milliliter; 95% confidence interval: 1.1 to 1.4]. VCY was associated with mortality in HIV-infected patients under combined antiretroviral therapy but did not overweigh the predictive value of the latest pVL. VCY might be more useful as a marker of persistent viral replication than for routine clinical care.

Dates et versions

hal-01115441 , version 1 (11-02-2015)

Identifiants

Citer

Catherine Chirouze, Valérie Journot, Vincent Le Moing, François Raffi, Lionel Piroth, et al.. Viremia Copy-Years as a Predictive Marker of All-Cause Mortality in HIV-1-Infected Patients Initiating a Protease Inhibitor-Containing Antiretroviral Treatment.. Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2015, 68 (2), pp.204-8. ⟨10.1097/qai.0000000000000416⟩. ⟨hal-01115441⟩
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