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Article Dans Une Revue Analytica Chimica Acta Année : 2014

Tandem mass spectrometry of low solubility polyamides

Résumé

The structural characterization of Polyamides (PA) was achieved by tandem mass spectrometry (MS/MS) with a Laser Induced Dissociation (LID) strategy. Because of interferences for precursor ions selection, two chemical modifications of the polymer end groups were proposed as derivatization strategies. The first approach, based on the addition of a trifluoroacetic acid (TFA) molecule, yields principally to complementary bn and yn product ions. This fragmentation types, analogous to those obtained with peptides or other PA, give only poor characterization of polymer end-groups.[1] A second approach, based on the addition of a basic diethylamine (DEA), permits to fix the charge and favourably direct the fragmentation. In this case, bn ions were not observed. The full characterization of ω end group structure was obtained, in addition to the expected yn and consecutive fragment ions.
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Dates et versions

hal-01107954 , version 1 (21-01-2015)

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Caroline Barrère, Marie Hubert-Roux, Carlos Afonso, Majed Rejaibi, Nasreddine Kebir, et al.. Tandem mass spectrometry of low solubility polyamides. Analytica Chimica Acta, 2014, 808, pp.3-9. ⟨10.1016/j.aca.2013.03.064⟩. ⟨hal-01107954⟩
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