One pot and selective intermolecular aryl- and heteroaryl-trifluoromethylation of alkenes by photoredox catalysis.

Aude Carboni (1) , Guillaume Dagousset (1) , Emmanuel Magnier (2) , Géraldine Masson (1)

1 ICSN - Institut de Chimie des Substances Naturelles
2 ILV - Institut Lavoisier de Versailles

We report herein the first photoredox-catalyzed intermolecular aryl- and heteroaryltrifluoromethylation of alkenes. Under the optimized conditions using Umemoto's reagent as a CF3 source, a wide range of styrenes can be readily difunctionalized, affording the corresponding trifluoromethylated adducts in up to 99% yield.

Domaines: Chimie

Aude Carboni, Guillaume Dagousset, Emmanuel Magnier, Géraldine Masson. One pot and selective intermolecular aryl- and heteroaryl-trifluoromethylation of alkenes by photoredox catalysis.. Chemical Communications, 2014, 50 (91), pp.14197-14200. ⟨hal-01104322⟩