AOM 06060 and AOM 08209) The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript ,
Invited members (informed of study design but did not participate in any decision-making study discussions Independent data-monitoring committee (advice on trial conduct and interruption Monitoring and statistical analysis Studypharm clinical research organizations Clinical investigators (responsible for patient enrollment and follow-up ) References 1 Prescription of anti-influenza drugs for healthy adults: a systematic review and meta-analysis, Lancet Infect Dis, vol.9, pp.537-545, 2009. ,
Neuraminidase inhibitors for preventing and treating influenza in healthy adults, Cochrane Database Syst Rev, vol.2, p.1265, 2010. ,
Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials, BMJ, vol.339, issue.aug10 1, p.3172, 2009. ,
DOI : 10.1136/bmj.b3172
Efficacy and Safety of the Neuraminidase Inhibitor Zanamivir in the Treatment of Influenzavirus Infections, New England Journal of Medicine, vol.337, issue.13, pp.874-880, 1997. ,
DOI : 10.1056/NEJM199709253371302
Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial, The Lancet, vol.355, issue.9218, pp.1845-1850, 2000. ,
DOI : 10.1016/S0140-6736(00)02288-1
Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza, JAMA, vol.283, issue.8, pp.1016-1024, 2000. ,
DOI : 10.1001/jama.283.8.1016
Factors Influencing the Effectiveness of Oseltamivir and Amantadine for the Treatment of Influenza: A Multicenter Study from Japan of the 2002--2003 Influenza Season, Clinical Infectious Diseases, vol.40, issue.9, pp.1309-1316, 2005. ,
DOI : 10.1086/429241
Clinical Effectiveness of Oseltamivir and Zanamivir for Treatment of Influenza A Virus Subtype H1N1 with the H274Y Mutation: A Japanese, Multicenter Study of the 2007???2008 and 2008???2009 Influenza Seasons, Clinical Infectious Diseases, vol.49, issue.12, pp.1828-1835, 2007. ,
DOI : 10.1086/648424
Early administration of oral oseltamivir increases the benefits of influenza treatment, Journal of Antimicrobial Chemotherapy, vol.51, issue.1, pp.123-129, 2003. ,
DOI : 10.1093/jac/dkg007
A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir, Virology Journal, vol.7, issue.1, p.53, 2010. ,
DOI : 10.1186/1743-422X-7-53
Lower Clinical Effectiveness of Oseltamivir against Influenza B Contrasted with Influenza A Infection in Children, Clinical Infectious Diseases, vol.44, issue.2, pp.197-202, 2007. ,
DOI : 10.1086/509925
Efficacy of Oseltamivir-Zanamivir Combination Compared to Each Monotherapy for Seasonal Influenza: A Randomized Placebo-Controlled Trial, PLoS Medicine, vol.48, issue.11, p.1000362, 2010. ,
DOI : 10.1371/journal.pmed.1000362.s006
URL : https://hal.archives-ouvertes.fr/inserm-00701161
Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients: from a predictive to a dynamic approach, Social Science & Medicine, vol.54, issue.10, pp.1481-1496, 2002. ,
DOI : 10.1016/S0277-9536(01)00125-3
Impact of maintenance therapy on hospitalization and expenditures for medicare beneficiaries with chronic obstructive pulmonary disease, The American Journal of Geriatric Pharmacotherapy, vol.8, issue.5, pp.441-453, 2010. ,
DOI : 10.1016/j.amjopharm.2010.10.002
Correlates of Medication Adherence Among Patients With Bipolar Disorder, The Primary Care Companion to The Journal of Clinical Psychiatry, vol.12, 2010. ,
DOI : 10.4088/PCC.09m00883yel
Socio-demographic differences in adherence to evidence-based drug therapy after hospital discharge from acute myocardial infarction: a population-based cohort study in Rome, Italy, Journal of Clinical Pharmacy and Therapeutics, vol.21, issue.7, 2011. ,
DOI : 10.1111/j.1365-2710.2010.01242.x
Predictors of adherence among Alzheimer's disease patients receiving oral therapy, Current Medical Research and Opinion, vol.26, issue.8, pp.1-957, 2010. ,
DOI : 10.1185/03007995.2010.493788
Six-item self-administered questionnaires in the waiting room: an aid to explain uncontrolled hypertension in high-risk patients seen in general practice, Journal of the American Society of Hypertension, vol.3, issue.3, pp.221-227, 2009. ,
DOI : 10.1016/j.jash.2008.12.004
Estrogen Regulates CCR Gene Expression and Function in T Lymphocytes, The Journal of Immunology, vol.174, issue.10, pp.6023-6029, 2005. ,
DOI : 10.4049/jimmunol.174.10.6023
Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation, The Journal of Immunology, vol.173, issue.10, pp.6098-6108, 2004. ,
DOI : 10.4049/jimmunol.173.10.6098
Clinical Pharmacokinetics of the Prodrug Oseltamivir and its Active Metabolite Ro 64-0802, Clinical Pharmacokinetics, vol.37, issue.6, pp.471-484, 1999. ,
DOI : 10.2165/00003088-199937060-00003
The Influence of Sex on Pharmacokinetics, Clinical Pharmacokinetics, vol.68, issue.5, pp.107-121, 2003. ,
DOI : 10.2165/00003088-200342020-00001
Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence, Drug Metab Dispos, vol.24, pp.1298-1306, 1996. ,
Somatic symptom reporting in women and men, Journal of General Internal Medicine, vol.330, issue.4, pp.266-275, 2001. ,
DOI : 10.1046/j.1525-1497.2001.016004266.x
The course of fever following influenza virus infection in children treated with oseltamivir, Journal of Medical Virology, vol.20, issue.6, pp.1065-1071, 2008. ,
DOI : 10.1002/jmv.21144
Effectiveness of Oseltamivir on Influenza and Influencing Factors, Journal of the Japanese Association for Infectious Diseases, vol.77, issue.6, pp.423-429, 2003. ,
DOI : 10.11150/kansenshogakuzasshi1970.77.423
Early Oseltamivir Treatment of Influenza in Children 1???3 Years of Age: A Randomized Controlled Trial, Clinical Infectious Diseases, vol.51, issue.8, pp.887-894, 2010. ,
DOI : 10.1086/656408
Factors associated with early hospital discharge of adult influenza patients, Antivir Ther, vol.12, pp.501-508, 2007. ,