Mixed Periodic Mesoporous Organosilica Nanoparticles and Core−Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery

Jonas Croissant (1) , Marie Maynadier (2) , Olivier Mongin (3) , Vincent Hugues (4) , Mireille Blanchard-Desce (4) , Xavier Cattoën (5, 1) , Michel Wong Chi Man (1) , Audrey Gallud (2) , Marcel Garcia (2) , Magali Gary-Bobo (2) , Laurence Raehm (1) , Jean-Olivier Durand (1) , Fabrice Salles (1)

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 ISCR - Institut des Sciences Chimiques de Rennes
4 ISM - Institut des Sciences Moléculaires
5 NEEL - OPTIMA - Optique et Matériaux

In this work, we describe the synthesis of new Mixed Periodic Mesoporous Organosilica Nanoparticles (MPMO NPs), combining the co-condensation of a tetra-trialkoxysilylated twophoton photosensitizer with bis-(triethoxysilyl)phenylene or ethylene. Novel gold core-MPMO shell systems are also described. The MPMO NPs are analyzed and characterized by multiple techniques, and are very efficient for anti-cancer drug delivery combined with two-photon therapy in MCF-7 breast cancer cells, leading down to 76% cancer cell death. MPMO NPs are thus very promising for nanomedicine applications.

Domaines: Matériaux; Chimie

Jonas Croissant, Marie Maynadier, Olivier Mongin, Vincent Hugues, Mireille Blanchard-Desce, et al.. Mixed Periodic Mesoporous Organosilica Nanoparticles and Core−Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery. Chemistry of Materials, 2014, 26 (24), pp.7214-7220. ⟨10.1021/cm5040276⟩. ⟨hal-01101634⟩