IMGT®, the international ImMunoGeneTics information system® 25 years on

Marie-Paule Lefranc (1) , Véronique Giudicelli (1) , Patrice Duroux (1) , Joumana Jabado-Michaloud (1) , Géraldine Folch (1) , Safa Aouinti (1) , Emilie Carillon (1) , Amélie Houles (1) , Typhaine Paysan-Lafosse (1) , Saida Hadi-Saljoqi (1) , Souphatta Sasorith (1) , Gérard Lefranc (1) , Sofia Kossida (1)

1 IGH - Institut de génétique humaine

IMGT(®), the international ImMunoGeneTics information system(®)(http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT(®) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT(®) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies. IMGT(®) is built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and 3D structures. The concepts include the IMGT(®) standardized keywords (identification), IMGT(®) standardized labels (description), IMGT(®) standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT(®) comprises 7 databases, 17 online tools and 15,000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Tools and databases are used in basic, veterinary and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA). IMGT(®) is freely available at http://www.imgt.org.

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]; Génétique

Marie-Paule Lefranc, Véronique Giudicelli, Patrice Duroux, Joumana Jabado-Michaloud, Géraldine Folch, et al.. IMGT®, the international ImMunoGeneTics information system® 25 years on. Nucleic Acids Research, 2015, 43, pp.D413-422. ⟨10.1093/nar/gku1056⟩. ⟨hal-01101330⟩