Metabolism: Pathogens love the poison

Stéphane Ménage (1) , Ina Attrée (2)

1 LCBM - UMR 5249 - Laboratoire de Chimie et Biologie des Métaux
2 BCI - Biologie du Cancer et de l'Infection

Itaconate is a metabolite secreted by activated macrophages that inhibits pathogen growth. Some pathogens use itaconate degradation enzymes to promote their survival and infectivity, highlighting metabolic pathways to be considered in host-pathogen interactions.

Domaines: Biochimie, Biologie Moléculaire; Toxicologie

Stéphane Ménage, Ina Attrée. Metabolism: Pathogens love the poison. Nature Chemical Biology, 2014, 10 (5), pp.326-327. ⟨10.1038/nchembio.1505⟩. ⟨hal-01081228⟩