Copper-Catalyzed Coupling of N-Tosylhydrazones with Amines: Synthesis of Fluorene Derivatives
Résumé
An original formation of one C-N bond and one C-C bond on the same carbenic center has been developed. This approach involves a copper-catalyzed cross-coupling reaction between 2’-bromo-biaryl-N-tosylhydrazones and different amines leading to 9H-fluoren-9-amine derivatives. This reaction proceeds under mild conditions in glycerol, an inexpensive and environmentally friendly solvent without adding any external ligand.