Copper-Catalyzed Coupling of N-Tosylhydrazones with Amines: Synthesis of Fluorene Derivatives

Abstract : An original formation of one C-N bond and one C-C bond on the same carbenic center has been developed. This approach involves a copper-catalyzed cross-coupling reaction between 2’-bromo-biaryl-N-tosylhydrazones and different amines leading to 9H-fluoren-9-amine derivatives. This reaction proceeds under mild conditions in glycerol, an inexpensive and environmentally friendly solvent without adding any external ligand.
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Contributor : Gilles Frison <>
Submitted on : Wednesday, November 5, 2014 - 11:10:08 PM
Last modification on : Friday, October 11, 2019 - 8:22:13 PM

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Jessy Aziz, Gilles Frison, Montserrat Gomez, Jean-Daniel Brion, Abdallah Hamze, et al.. Copper-Catalyzed Coupling of N-Tosylhydrazones with Amines: Synthesis of Fluorene Derivatives. ACS Catalysis, American Chemical Society, 2014, 4, pp.4498-4503. ⟨10.1021/cs5014877⟩. ⟨hal-01080685⟩

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