Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication.

Abstract : A bioassay-guided purification of an EtOAc extract of the leaves of Croton mauritianus using a chikungunya virus-cell-based assay led to the isolation of 12-O-decanoylphorbol-13-acetate (1) and the new 12-O-decanoyl-7-hydroperoxy-phorbol-5-ene-13-acetate (2), along with loliolide, vomifoliol, dehydrovomifoliol, annuionone D and bluemol C. The planar structure and the relative configuration of compound 2 were elucidated based on spectroscopic analysis, including 1D- and 2D-NMR experiments, mass spectrometry, and comparison with literature data. Compounds 1 and 2 inhibited chikungunya virus-induced cell death in cell culture with EC50s of 2.4±0.3 and 4.0±0.8 μM, respectively.
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https://hal.archives-ouvertes.fr/hal-01071226
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Submitted on : Friday, October 3, 2014 - 2:24:23 PM
Last modification on : Monday, September 2, 2019 - 9:41:42 AM

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Nina Corlay, Leen Delang, Emmanuelle Girard-Valenciennes, Johan Neyts, Patricia Clerc, et al.. Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication.. Fitoterapia, Elsevier, 2014, 97, pp.87-91. ⟨10.1016/j.fitote.2014.05.015⟩. ⟨hal-01071226⟩

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