NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel

Corinne Arpin (1) , Patrick Noury , Delphine Boraud , Laure Coulange (1) , Alain Manetti , Catherine André (2) , Fatima M'Zali , Claudine Quentin (1)

1 MFP - Microbiologie Fondamentale et Pathogénicité
2 IGDR - Institut de Génétique et Développement de Rennes

A carbapenem-resistant Klebsiella pneumoniae strain, Kp5196, was responsible for an uncomplicated cystitis in a patient living at home and without history of foreign travel. This isolate produced the metallocarbapenemase NDM-1 and was resistant to all antibiotics except tetracyclines and colistin. The K. pneumoniae strain belonged to sequence type ST15, and bla(NDM-1) was carried by a nontypeable conjugative plasmid. Two months later, a similar ST15 isolate, Kp5241, was present in the patient but was additionally colistin resistant.

Mots clés: Anti-Bacterial Agents; beta-Lactamases; Colistin; Drug Resistance; Multiple; Bacterial; Humans; Klebsiella pneumoniae; Plasmids; Tetracyclines

Domaines: Génétique

Corinne Arpin, Patrick Noury, Delphine Boraud, Laure Coulange, Alain Manetti, et al.. NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel. Antimicrobial Agents and Chemotherapy, 2012, 56 (6), pp.3432--3434. ⟨10.1128/AAC.00230-12⟩. ⟨hal-01068341⟩