Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Oncology Année : 2012

Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas.

Laurence H Baker
  • Fonction : Auteur
Scott M Schuetze
  • Fonction : Auteur
Anthony W Tolcher
  • Fonction : Auteur
Gina Z d'Amato
  • Fonction : Auteur
Monica M Mita
  • Fonction : Auteur
Kamalesh K Sankhala
  • Fonction : Auteur
Lori Berk
  • Fonction : Auteur
Victor M Rivera
  • Fonction : Auteur
Tim Clackson
  • Fonction : Auteur
John W Loewy
  • Fonction : Auteur
Frank G Haluska
  • Fonction : Auteur

Résumé

PURPOSE: Ridaforolimus is an inhibitor of mammalian target of rapamycin, an integral component of the phosphatidyl 3-kinase/AKT signaling pathway, with early evidence of activity in sarcomas. This multicenter, open-label, single-arm, phase II trial was conducted to assess the antitumor activity of ridaforolimus in patients with distinct subtypes of advanced sarcomas. PATIENTS AND METHODS: Patients with metastatic or unresectable soft tissue or bone sarcomas received ridaforolimus 12.5 mg administered as a 30-minute intravenous infusion once daily for 5 days every 2 weeks. The primary end point was clinical benefit response (CBR) rate (complete response or partial response [PR] or stable disease ≥ 16 weeks). Safety, progression-free survival (PFS), overall survival (OS), time to progression, and duration of response were also evaluated. RESULTS: A total of 212 patients were treated in four separate histologic cohorts. In this heavily pretreated population, 61 patients (28.8%) achieved CBR. Median PFS was 15.3 weeks; median OS was 40 weeks. Response Evaluation Criteria in Solid Tumors (RECIST) confirmed response rate was 1.9%, with four patients achieving confirmed PR (two with osteosarcoma, one with spindle cell sarcoma, and one with malignant fibrous histiocytoma). Archival tumor protein markers analyzed were not correlated with CBR. Related adverse events were generally mild or moderate and consisted primarily of stomatitis, mucosal inflammation, mouth ulceration, rash, and fatigue. CONCLUSION: Single-agent ridaforolimus in patients with advanced and pretreated sarcomas led to PFS results that compare favorably with historical metrics. A phase III trial based on these data will further define ridaforolimus activity in sarcomas.

Domaines

Cancer

Dates et versions

hal-01058262 , version 1 (26-08-2014)

Identifiants

Citer

Sant P Chawla, Arthur P Staddon, Laurence H Baker, Scott M Schuetze, Anthony W Tolcher, et al.. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas.. Journal of Clinical Oncology, 2012, 30 (1), pp.78-84. ⟨10.1200/JCO.2011.35.6329⟩. ⟨hal-01058262⟩
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